Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte
plasma membranes in rat brain and spinal cord.
Aquaporin 4 was present in high amounts in astrocytes and ependymocytes and in low amounts in the choroidal plexus epithelia and leptomeningeal cells.
Positivity was intense in choroid plexus cells, inner and outer glia limitans, and leptomeninges and was moderate in ependymocytes and the perivascular endfeet.
The cell of origin is thought to be the specialized ependymocytes
of the subcommissural organ (2).
3) The cortical location of the great majority of these tumors, however, argues against derivation from native ependymocytes
At a higher magnification, the vimentin-IR was detected in glial cells, namely in ependymocytes that compose the wall of the 3V, and in astrocytes surrounding blood vessels (Fig.
The functional significance of vimentin expression in ependymocytes of the 3V wall and adjacent astrocytes of PV may be to increase the cell flexibility in ionic (K+) clearance during the repeated electrical activation of MCN.