A glial neoplasm of the central nervous system, occurring typically in childhood; the prototype tumor cells resemble ependymoblasts.
[ependymoblast + G. -ōma, tumor]
Farlex Partner Medical Dictionary © Farlex 2012
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(1) The term PNET was coined by Hart and Earle (2) in 1973 for predominantly undifferentiated tumours of the cerebellum that did not match the diagnostic criteria for neuroblastoma, ependymoblastoma, medulloblastoma or pineal parenchymal tumours.
This trio of uniformly aggressive embryonal neoplasms, including the embryonal tumor with abundant neuropil and true rosettes, the ependymoblastoma, and the medulloepithelioma, are histologically united by the shared feature of lumen-forming, multilayered, ependymoblastic" rosettes.
The patients entered into this protocol exhibited tumors that represented the spectrum of embryonal tumors of childhood, including MB, AT/RT, PB, CNS PNET, ependymoblastoma, and choroid plexus carcinoma.
(118,119) These are typically pediatric tumors and include medulloblastoma, supratentorial "central" PNET, medulloepithelioma, ependymoblastoma, and atypical teratoid rhabdoid tumor (AT/RT).
Of these, 4 cases (3.9%) were found to show the Azzopardi phenomenon (3 medulloblastomas and 1 ependymoblastoma).