eotaxin

eotaxin

(ē'ō-tak-sin),
A chemokine with chemoattractant properties for eosinophils, but not for leukocytes.
[eosinophil + G. taxis, orderly arrangement, + -in]

CCL11

A gene on chromosome 17q21.1-q21.2 that encodes eotaxin-1, a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. Eotaxin-1/CCL11 binds CCR3, is chemotactic for eosinophils—but not mononuclear cells or neutrophils—and is involved in eosinophilic type inflammatory responses (e.g., atopic dermatitis, allergic rhinitis, asthma and parasitic infections).

eotaxin

(e-o-toks'in) [Gr. eos, dawn (rose-colored) + (chemo)taxin]
A chemokine that specifically attracts eosinophils to particular tissues (e.g., to bronchial tissues in asthma or to the skin in contact dermatitis). Tumor necrosis factor alpha stimulates its release. See: chemotaxis; cytokine
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The cytokines detected were IFNI3, IL-10, IL-12p70, IL-13, IL-2, IL-5, IP-10, MiP-1[alpha], MiP-1[beta], IL-6, IL1-RA, GM-CSF, RANTES, IL-1[beta], Eotaxin, Basic FGF, VEGF, PDGF-[beta], MCP-1, IL-8, IL15, IL-17, G-CSF, IL-12p70, IL17A, IL-9 and TNF-[alpha].
The 27 cytokines and chemokines investigated were IL-1[beta], IL-1r, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12p70, IL-13, IL-15, IL-17a, Eotaxin, basic PDGF, G-CSF, GM-CSF, IFN-[gamma], IP-10, MCP-1(MCAF), MIP-1[alpha], MIP-1[beta], PDGF-BB, RANTES, TNF- [alpha] and VEGF.
Studies with advanced cancer patients have shown reductions in C-reactive protein; interleukins la, 2, and 8; tumor necrosis factor a; and eotaxin with IV C therapy.
The material is derived from green citrus unshiu, which contains synephrine and hesperidin, which are said to regulate eotaxin synthesis, and naringin, which decreases histamine release.
Serum eotaxin levels in patients with chronic spontaneous urticaria.
They display increased responsiveness, adhesiveness, migration, and degranulation [10, 11] and are characterized by upregulated secretion of their mediators, for example, eosinophilic cationic protein [12] or eotaxin [13, 14].
The concentrations of the following circulation cytokines and chemokines were measured: IL-1[alpha], IL-1[beta], IL-1ra, IL-2, sIL-2R[alpha], IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12(p40), IL-12(p70), IL-13, IL-15, IL-17a, sCD40L, EGF, Eotaxin, FGF2, Flt-3 ligand, Fractalkine, G-CSF, GM-CSF, GRO, IFNa2, IFN-[gamma], IP-10, MCP-1, MCP-3/CCL7, MDC/CCL22, MIP-1a, MIP-1[beta], TGF[alpha], TNF[alpha], TNF[beta], and VEGF.
Imai et al., "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3," The Journal of Biological Chemistry, vol.
Mao et al., "High plasma levels of MCP-1 and eotaxin provide evidence for an immunological basis of fibromyalgia," Experimental Biology and Medicine, vol.
This assay kit measured protein concentrations of chemokines: eotaxin, fractalkine, interferon-gamma inducible protein-10 (IP-10), monocyte inflammatory protein (MCP)-1, macrophage inhibitory protein (MIP)-1a, and RANTES; proinflammatory cytokines: granulocyte macrophage colony-stimulating factor (GMCSF), interleukin--(IL-) 1[beta], IL-2, IL-12(p40/p70), IL-6, IL7, IL-8, IL-15, IL-17, tissue necrosis factor--(TNF-) [alpha], and interferon- (IFN-)[gamma]; anti-inflammatory cytokines: IL-1RA, IL-4, IL-5, IL-10, IL-13, and IFN-a; and growth factors: vascular endothelial growth factor (VEGF), melanoma growth stimulatory activity (GRO), epidermal growth factor (EGF), fibroblast growth factor (FGF)-2, and platelet-derived growth factor (PDGF-AA and PDGF-BB).
Finally, in another ocular fluid, the aqueous humour; higher levels of proteins involved in AD pathology such as [beta]-amyloid peptides; and a series of chemokines, including eotaxin, eotaxin 3, and interleukin [IL]-8 (160) were detected in cataract surgery patients.
Biochemical Wilks's Partial F P Tolerance 1-toler marker lambda Wilks's 5 BDNF 0.636 0.891 5.733 0.021 0.851 0.148 BLC 0.601 0.943 2.840 0.099 0.796 0.204 Eotaxin 0.589 0.963 1.818 0.184 0.582 0.418 Eotaxin-2 0.581 0.976 1.143 0.290 0.678 0.322 E-Selectin 0.571 0.993 0.332 0.567 0.393 0.607 ICAM-1 0.577 0.983 0.815 0.371 0.661 0.339 IGFBP-1 0.623 0.911 4.603 0.037 0.724 0.276 IGFBP-2 0.567 0.100 0.001 0.995 0.512 0.487 L-Selectin 0.603 0.941 2.961 0.092 0.397 0.602 MIP-1d 0.567 0.100 0.004 0.951 0.691 0.309 MIP-3b 0.567 0.100 0.002 0.966 0.836 0.164 PECAM-1 0.657 0.863 7.453 0.009 0.779 0.221 VCAM-1 0.571 0.993 0.336 0.565 0.634 0.366 Table 4: Predictive value of selected markers marked with discriminant analysis by stepwise forward selection method.