eosinophilic gastroenteritis


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gastroenteritis

 [gas″tro-en″tĕ-ri´tis]
inflammation of the lining of the stomach and intestine. Psychologic causes may include fear, anger, and other forms of emotional upset. Allergic reactions to certain foods can cause the condition, as can irritation by excessive use of alcohol. Severe gastroenteritis, with such symptoms as headache, nausea, vomiting, weakness, diarrhea, and gas pains, may result from various infectious and contagious diseases, such as typhoid fever, influenza, and food poisoning.
eosinophilic gastroenteritis a disorder, commonly associated with intolerance to specific foods, marked by infiltration of the mucosa of the small intestine and frequently the stomach by eosinophils, with edema but without vasculitis and by eosinophilia of the peripheral blood. Symptoms depend on the site and extent of the disorder.

e·o·sin·o·phil·ic gas·tro·en·ter·i·tis

disorder comprising abdominal pain, malabsorption, often obstructive symptoms, associated with peripheral eosinophilia and areas of eosinophilic infiltration of the stomach, small intestine, and colon. May have an allergic etiology and responds to elimination diet in some patients; corticosteroid therapy is also effective.

eosinophilic gastroenteritis

A rare (about 300 cases reported in the world literature) heterogeneous condition characterised by abundant eosinophils in the lamina propria, especially of the stomach and less commonly of the small and large intestine.

Aetiology
Idiopathic or associated with allergies (e.g., asthma, atopic eczema, food allergy—usually to milk or soy protein), connective tissue disease (e.g., scleroderma, polymyositis, and dermatomyositis), Crohn’s disease, and parasites (e.g., anisakiasis).

Clinical findings
Nausea, vomiting, diarrhoea, weight loss, abdominal pain (linked to ingestion of specific foods), fever, rebound tenderness, mesenteritis.

Lab
Often with increased eosinophils in peripheral blood.
 
Pathology
Eosinophils in mucosa, fibrosis of muscularis propria with thickening and rigidity with outlet obstruction.

Management
May respond to elimination diet; up to 90% respond to corticosteroids.

e·o·sin·o·phil·ic gas·tro·en·ter·i·tis

Disorder comprising abdominal pain, malabsorption, often obstructive symptoms, associated with peripheral eosinophilia and areas of eosinophilic infiltration of the stomach, small intestine, and colon.
References in periodicals archive ?
Zinsmeister, "Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues," Gut, vol.
Jeffries, "Eosinophilic gastroenteritis," Medicine, vol.
Prussin, "Eosinophilic gastroenteritis and related eosinophilic disorders," Gastroenterology Clinics of North America, vol.
Castillo Diaz de Leon, "Eosinophilic gastroenteritis: case report and review in search for diagnostic key points," Case Reports in Gastrointestinal Medicine, vol.
Tenias, "Efficacy of dietary treatment for inducing disease remission in eosinophilic gastroenteritis," Journal of Pediatric Gastroenterology and Nutrition, vol.
Ultrasonography is a useful tool for detecting non-mucosal eosinophilic gastroenteritis in patients without peripheral hyper-eosinophilia.
Most patients with eosinophilic gastroenteritis respond dramatically to oral prednisolone, recommended daily.
Combining the cases of eosinophilic gastroenteritis with cases of IBD failed to detect any significant difference between them and patients with celiac disease by evaluation staining in surface villi and crypt (P value = 0.3536 and1, resp.).
About Eosinophilic Gastritis, Eosinophilic Gastroenteritis, and Eosinophilic Esophagitis
Eosinophilic gastritis, eosinophilic gastroenteritis, and Eosinophilic Esophagitis are severe orphan inflammatory diseases characterized by the presence of high levels of eosinophils in the stomach, duodenum, or esophagitis, respectively.

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