A few examples include the esophagus (
eosinophilic esophagitis), stomach (
eosinophilic gastritis), or the lungs (
eosinophilic asthma).
Fasenra is AstraZeneca's first respiratory biologic medicine and is currently approved as an add-on maintenance treatment for severe,
eosinophilic asthma in the US, EU, Japan and other countries.
This 12-week biomarker study is planned to randomize approximately 100 patients with
eosinophilic asthma to investigate the eosinophil response to three different doses of oral dexpramipexole.
Heart transplantation patients were significantly more likely to develop asthma and autoimmunity, while liver transplantation patients had a significantly greater incidence of food allergies and
eosinophilic gastrointestinal disease.
We took into consideration for differential diagnosis several scleroderma-like disorders:
eosinophilic fasciitis, localized and systemic sclerosis, nephrogenic systemic fibrosis, scleromyxedema, scleredema and eosinophilia myalgia syndrome.
Another eosinophil-derived protein,
eosinophilic cationic protein (ECP), has been studied and shown to be accurate in the clinical monitoring of asthma and allergic rhinoconjunctivitis (11).
Eosinophilic disorders of the gastro-intestinal tract: an update.
Eosinophilic angiocentric fibrosis presents most commonly as a lesion in the nasal cavity in patients with a prolonged history of nasal obstruction or deformity.
Our clinical trials for Fasenra in severe,
eosinophilic asthma show it depletes eosinophils and we are exploring the potential of this medicine to address unmet medical needs in other eosinophil-driven diseases.
have noted that both circulating and muscle eosinophilia tend to be more prominent in LGMD2A children than in adults,[3] thus proposing that
eosinophilic infiltration is the early or even primary event of pathogenesis.
The findings of the study make a case for introducing routine screening for celiac disease among
eosinophilic esophagitis patients.
Dr Mansoor's study analysed the diagnostic data of more than 35 million US residents collected over a five-year period and found that patients with
eosinophilic esophagitis, a debilitating autoimmune disease characterised by chronic inflammation of the esophagus, are nine times more likely to have celiac disease than the general public.
