The optimal cutoff point for eosinopenia determined by Youden's index in this study is [less than or equal to]20/mcl; while eosinopenia showed the lowest sensitivity among the five biomarkers included in our study, it showed the highest specificity (53.
We strongly believe that eosinopenia along with increased leucocyte and neutrophil counts, increased total bilirubin level, and increased neutrophil/leucocyte ratio can predict perforation as a biomarker panel, especially in settings where CT use is limited or unavailable.
We would like to note that while AA patients with eosinopenia prior to operation are more likely to suffer perforation, eosinopenia is not an absolute marker for perforation.
9]/l were not measurable by this automated method and were defined as eosinopenia in this study.
The associations between unplanned ICU re-admission during the same hospitalisation or mortality after ICU discharge and eosinopenia were tested with univariate analyses followed by multivariate analysis.
and degenerating eosinophilic leucocytes in blood.
Recently, there has been a resurgence of interest in using eosinopenia as a biomarker of infection.
We hypothesised that eosinopenia is a reliable marker of bloodstream infection in both hospitalised paediatric and adult patients, and conducted a case-control study to assess its diagnostic accuracy as a marker of bloodstream infection, and whether eosinopenia could give additional diagnostic information when combined with the usual conventional markers of infection such as serum CRP concentrations and neutrophil counts.
While profound blood and tissue eosinophilia is a typical feature of parasitic helminth infection (8), eosinopenia appears to be associated with bacterial infections including bloodstream infections (6,7,9,10.
Whether eosinopenia or a combination of eosinopenia and CRP can be used to predict bloodstream infections in critically ill patients remains uncertain.