The optimal cutoff point for eosinopenia
determined by Youden's index in this study is [less than or equal to]20/mcl; while eosinopenia
showed the lowest sensitivity among the five biomarkers included in our study, it showed the highest specificity (53.1% and 76.8%, respectively).
As such, eosinopenia
is expected in a number of clinical conditions including bloodstream infections, viral infections, therapy with corticosteroids and catecholamines and physiological stress (16-18).
observed that both sustained eosinopenia
and a high neutrophil to lymphocyte count ratio were independent markers of mortality in patients with bacteremia .
Eosinophilia is a useful marker for infection and eosinopenia
is correlated with a poor clinical outcome in fulminant infection." Defective T -cell responses coupled with autoinfection cycles account for heavy worm burdens in some immunosuppressed individuals and lead to hyperinfection syndrome and disseminated strongyloidiasis.
A decrease in the eosinophil count (eosinopenia
) is seen with an increase in adrenal steroids (stress, shock, etc.) or adrenocortical hyperfunction (Corbett, 2000; Kee, 1999).
Other consequences of glucocorticoid release, such as neutrophilia, lymphopenia, and eosinopenia
(stress leucogram), could have developed by the time the blood samples were collected.
Stress-induced corticosteroids inhibit immune function further by also causing eosinopenia
, T-cell blastogenesis, granulocytosis, and inhibited basophil, mast cell, and neutrophil function. Increased levels of cortisol have also been associated with decreased lymphocyte resonse to mitogen stimulation and diminished ability to destroy foreign cells. Patients who undergo neurological surgery often receive exogenous corticosteroids and consequently end up with immunosuppression.
Dentro de los efectos colaterales mas sobresalientes indicados por Kemmerlin  y Van Der KolK , son dignos de mencionar: la gluconeogenesis, a partir de la grasa y de las proteinas tisulares; la hiperglicemia; la glucosuria; la eosinopenia
; retencion de sodio; edema; perdidas de potasio, (debido a la poliurea) y la polidipsia.
A mechanism for the eosinopenia
induced by cortisone and epinephrine.
in 39 (76.47%), Leucocytosis in 7 (13.73%) and Leukopenia in 5 (9.8%), whereas normal Absolute Eosinophil Count were seen in 47 (92.16%) and Eosinopenia
in 4 (7.84%).
BRYANS (1955) studied horses experimentally infected with the incidental (non-adapted) serovar Pomona and detected leucocytosis, neutrophilia, eosinopenia
, and lymphopenia, in addition to high serum bilirubin concentrations and albuminuria.
The classic clinical picture of kala-azar includes fever, cachexia, hepato-splenomegaly (splenomegaly usually predominates), pancytopenia (anemia, thrombocytopenia and leucopenia, with neutropenia, marked eosinopenia
, and a relative lymphocitosis and monocytosis), and hypergammaglobulinemia (mainly IgG from polyclonal B-cell activation) with hypoalbuminemia [1,5].