entry inhibitor


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entry inhibitor

Any agent that prevents a pathogen (e.g., human immunodeficiency virus) from binding to cell membranes and infecting cells.
Synonym: attachment inhibitor
See also: inhibitor
References in periodicals archive ?
Adelsberger et al., "Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors that target the gp120-binding domain of CD4," Journal of Virology, vol.
Since hepatitis Delta virus uses the same receptor as HBV, HBV entry inhibitors are equally effective against both viruses [49].
In addition, newer agents with novel mechanisms of action, such as HIV entry inhibitors (which inhibit the three steps of HIV entry: CD4 attachment, chemokine co-receptor binding and membrane fusion) and HIV integrase inhibitors, are also under investigation.
* With several major phase II studies in progress or set to launch, hope for oral entry inhibitors is at an all-time high.
Other investigators working on entry inhibitors have made new and exciting observations that may provide a glimpse into the future of entry inhibitors.
Oliveira et al., "Maraviroc and other HIV-1 entry inhibitors exhibit a class-specific redistribution effect that results in increased extracellular viral load," Antimicrobial Agents and Chemotherapy, vol.
The antiretroviral classes new in the mid-1990s--protease inhibitors and nonnucleosides--were not joined by entry inhibitors and integrase inhibitors until 2003 and 2007.
T-20 is one of the entry inhibitors which are approved by FDA.
[4] There are very few data on the entry inhibitors and integrase inhibitors, although some early data indicate the possibility of an improved metabolic and lipid profile.
Mitsuya also made a direct contribution to advancing research and development into entry inhibitors and the clinical implementation of
All the other products mentioned are called HIV entry inhibitors and block HIV infection.