Adelsberger et al., "Discovery of small-molecule human immunodeficiency virus type 1 entry inhibitors
that target the gp120-binding domain of CD4," Journal of Virology, vol.
Since hepatitis Delta virus uses the same receptor as HBV, HBV entry inhibitors
are equally effective against both viruses .
In addition, newer agents with novel mechanisms of action, such as HIV entry inhibitors
(which inhibit the three steps of HIV entry: CD4 attachment, chemokine co-receptor binding and membrane fusion) and HIV integrase inhibitors, are also under investigation.
* With several major phase II studies in progress or set to launch, hope for oral entry inhibitors
is at an all-time high.
Trimeris also has a second-generation entry inhibitor
in early clinical trials.
Other investigators working on entry inhibitors
have made new and exciting observations that may provide a glimpse into the future of entry inhibitors
Oliveira et al., "Maraviroc and other HIV-1 entry inhibitors
exhibit a class-specific redistribution effect that results in increased extracellular viral load," Antimicrobial Agents and Chemotherapy, vol.
The antiretroviral classes new in the mid-1990s--protease inhibitors and nonnucleosides--were not joined by entry inhibitors
and integrase inhibitors until 2003 and 2007.
T-20 is one of the entry inhibitors
which are approved by FDA.
 There are very few data on the entry inhibitors
and integrase inhibitors, although some early data indicate the possibility of an improved metabolic and lipid profile.
Mitsuya also made a direct contribution to advancing research and development into entry inhibitors
and the clinical implementation of
All the other products mentioned are called HIV entry inhibitors
and block HIV infection.