Mehta's findings instead indicate that there is a third key actor in this complex dialogue, the entorhinal cortex
, and that the neocortex is driving the entorhinal cortex
, which in turn behaves as if it is remembering something.
* MRI measurements: In the very early stages of AD, the hippocampus and entorhinal cortex
are smaller than normal.
Different asymmetry patterns were identified in the medial side of the brain, specifically located in the limbic system including the anterior cingulate cortex and the entorhinal cortex
. Leftward lateralization was observed in the entorhinal cortex
in MCI nonconverters from baseline to the last visit, as well as in the rostral anterior cingulate gyrus in converters during all visits.
Thom, "Quantitative neuropathology of the entorhinal cortex
region in patients with hippocampal sclerosis and temporal lobe epilepsy," Epilepsia, vol.
Low scores on the University of Pennsylvania Smell Identification Test (UPSIT) are linked to a thinning of the entorhinal cortex
the brain region where amyloid plaques are thought to first appear as Alzheimer's disease takes hold, reported at the Alzheimer's Association International Conference.
Tau immunostaining demonstrated characteristic pathology of argyrophilic grains in the amygdala, entorhinal cortex
, and hippocampus proper as well as scattered oligodendroglial "coiled" bodies in white matter.
Moser, "Topography of head direction cells in medial entorhinal cortex
," Current Biology, vol.
The dentate gyrus receives afferent connections from the entorhinal cortex
, which act as an input region.
Moser, "Spatial representation in the entorhinal cortex
," Science, vol.
Contextual information from the parietal "where" pathway enters the hippocampus through the medial entorhinal cortex
(MEC), which, with the discovery of spatially selective grid and boundary cells, has been shown to depend on an animal's surroundings [29, 30].
The entorhinal cortex
(EC) and postrhinal cortex (POR) were then dissected out based on the previous studies [36-38] (see Figure 1 of Liu et al.