Secukinumab is effective in reducing dactylitis and enthesitis
using multiple measures in patients with psoriatic arthritis: results of a phase 3 randomized, multicenter, double-blind, placebo-controlled study (FUTURE 2).
In addition to the primary endpoint of ACR20 response at week 24, multiple secondary endpoints were assessed that included ACR50/70, resolution of soft tissue inflammation (enthesitis
and dactylitis), disease activity (DAS-28 CRP), improvement in physical function (HAQ-DI), skin clearance, and quality of life (SF-36 PCS and MCS).
 The presence of enthesitis
or perifascial fluid collection eliciting a Doppler signal may suggest spondyloarthropathy.
The presence of synovitis, capsulitis, and enthesitis
or structural changes, in the context of erosions, subchondral sclerosis, periarticular fat deposition and ankylosis are suggestive of and are not sufficient alone to make the diagnosis of axial spondyloarthropathy (9).
Out of the 30 patients who presented in our outpatient department, maximum number were Enthesitis
related arthritis (ERA) whose count was 11, nine out of 30 patients had a Polyarticular variety, followed by 5 systemic onset or SOJIA, and only 3 oligoarticular or OJIA.
related arthritis, present in 5% of JIA patients older than 6 years, affecting usually the Achilles tendon and plantar fascia;
* Keep an eye out for enthesitis
, a distinctive feature of PsA (common sites including the Achilles tendon insertion, plantar fascia, and lateral epicondyles) (11,12)
None of the patients was observed to have psoriatic, enthesitis
and undifferentiated categories of JIA (table-I).
Patients with ReA usually present with asymmetrical monoarthritis, mostly of large joints of the lower extremities, but may also present with enthesitis
, bursitis, conjunctivitis, anterior acute uveitis as well as various skin changes .
Capsulitis and enthesitis
manifest as increased signal on STIR, fat-suppressed T2, and contrast-enhanced images.
Symptoms such as peripheral arthritis, enthesitis
, and uveitis are the most common non-axial involvements seen in AS patients (6).
Of 17 symptomatic patients who participated, 1 had arthritis in the ankle, 14 had [greater than or equal to] 1 tender joint, and 10 had enthesitis
, tendinitis, or tenosynovitis at examination.