Several peptides and hormones present in the enteroinsular
axis play significant roles in body homeostasis, and their secretion is altered by physical exercise (28).
These findings clearly indicate that chronic alcohol exposure induces a [beta]-cell dysfunction and not an enteroinsular incretin dysfunction, because the decrease in insulin response compared with the control group also was observed when glucose was administered intravenously.
The enteroinsular axis and endocrine pancreatic function in chronic alcohol consumers: Evidence for early beta-cell hypofunction.
Glucose homeostasis and the enteroinsular
axis in the horse: a possible role in equine metabolic syndrome.
The metabolic, hormonal, and neuronal influences on the endocrine pancreas are collectively referred to as the "enteroinsular
This is probably due to yet to be understood role of enteroinsular
axis leading to enhanced beta-cell sensitivity and reducing the peripheral insulin resistance.
Donini, "The enteroinsular
axis and the recovery from type 2 diabetes after bariatric surgery," Obesity Surgery, vol.
[26-29] The precise mechanisms by which TCF7L2 variants increase risk are not well understood, although various lines of evidence suggest that they involve the enteroinsular
axis, impaired insulin secretion and possibly reduced P cell proliferation.
Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular
axis in transducing the glucoregulatory actions of DPP-IV inhibitors.