Other theories include the possibility that carbapenems may limit oral VPA absorption, decrease VPA enterohepatic recirculation
, and increase VPA metabolism.
This is called enterohepatic recirculation
. Binders ensure the products of Phase 1, 2 & 2.5 Detoxification are actually excreted fully from the body through elimination.
The partner to the gut is the liver and there is an amazing connection called the enterohepatic recirculation
, which helps the body process chemicals in the liver and prepare it for non-toxic excretion in the gut.
Colchicine is rapidly absorbed in the gastrointestinal (GI) tract and undergoes first-pass hepatic metabolism with enterohepatic recirculation
of metabolites prior to excretion via the biliary tract.
The concentration-time profile of EF showed a double peak-shaped curve indicating the possibility of enterohepatic recirculation
of EF in geese.
For most antibiotics, the mechanism of interference is at the level of the enterohepatic recirculation
of the contraceptives.
Deconjugation and reabsorption of some bilirubin for enterohepatic recirculation
As a result of the prolonged absorption time and enterohepatic recirculation
of DDS, methaemoglobinaemia may persist for several days following DDS ingestion.
This would preclude enterohepatic recirculation
in humans, in contrast to rats, in which intestinal [beta]-glucuronidases could break down excreted conjugate and liberate BPA for systemic reabsorption.
Most important is the fact that ethinyloestradiol undergoes eventual enterohepatic recirculation
. Initially, ethinyloestradiol is subject to first-pass metabolism in the gut mucosa and liver.
Serum concentrations of free 8-PN showed rapid drug absorption and secondary peaks suggestive of marked enterohepatic recirculation
. Independent of the treatment group, approximately 30% of the dose was recovered in excreta as free compound or conjugates over the 48-h observation period.
A high fiber diet reduces circulating estrogens by reducing enterohepatic recirculation