FXR plays a key role in controlling the enterohepatic circulation
of BS, largely by directly regulating the expression of several hepatobiliary transporters (Figure 1).
Caption: Figure 2: Pathophysiology of enterohepatic circulation
: bile acids (BAs) excreted in the intestinal lumen are mainly reabsorbed in the ileum through the apical sodium-dependent bile acid transporter (ASBT) and return to the liver through the portal vessels.
is a well-documented process that is generally associated with bile acid metabolism.
A 388A>G polymorphism of this gene has been reported to considerably reduce the transporting property of drugs like pravastatin (17), and may be involved in the [Na.sup.+] independent pathway of bile salt uptake in enterohepatic circulation
. Therefore, we undertook this study to estimate the prevalence of SLCO1B1 388A>G polymorphism in north Indian population and to evaluate its association with gallstone disease.
We performed a pilot study to understand whether puerarin undergoes an efficient enterohepatic circulation
. Time-dependent biliary excretion of puerarin in a rat following portal vein infusion of puerarin is shown in Fig.
The coming of age of our understanding of the enterohepatic circulation
of bile salts.
Apparently, iodine is not reduced to iodide by the liver during enterohepatic circulation
. There was no significant difference in the iodide measured following the addition of reductant to serum for the conversion of iodine to iodide or following the addition of 10 times more reductant for the conversion of iodate to iodide.
Physicians should perform gastric ravage and administer repeated doses of activated charcoal to remove any unabsorbed Amanita and to interrupt the enterohepatic circulation
of the toxin (2,4,5).
 Rise in indirect bilirubin in this type is due to enhancement of enterohepatic circulation
. Moreover, presence of large amounts of bilirubin in meconium & delay in emptying of meconium have been shown to contribute to an increase in serum bilirubin levels in early days of life further increasing intestinal biliary absorption.
2009), changes in enterohepatic circulation
(Meijer et al.
Ezetimibe is conjugated to its active glucuronide form, which undergoes enterohepatic circulation
. This increases its elimination half-life to about 22 hours.