Keywords: Algae; Trypanosoma; Leishmania; Plasmodium; Fatty acid synthase; Enoyl-ACP reductase (FabI)
The unique enzyme enoyl-ACP reductase (FabI) of Plasmodium commits the final reduction step during the fatty acid elongation process, therefore representing an excellent target for the development of novel antiplasmodial agents (Surolia and Surolia, 2001).
falciparum enoyl-ACP reductase (FabI) inhibition assay
Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP reductase, a crucial enzyme in fatty acid biosynthesis.
Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum.