Scientists have known for some time that triclosan can halt malaria parasites' growth at the blood stage of the infection by inhibiting the action of an enzyme known as enoyl
reductase (ENR), which is involved in production of fatty acids.
The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl
reductase: adduct affinity and drug resistance.
Six different band patterns were identified at the promoter region of inhA gene, which codes for the NADH enoyl
ACP reductase enzyme and sensitivity to INH.
hatG encoding catalase peroxidase, inhA encoding the enoyl
acyl carrier protein (ACP) reductase, has A encoding aketoacyl ACP synthase and ahpC encoding alkylhydroperoxide reductase.
The assay has an additional advantage over other line probe assays because the Genotype MTBDRplus assay identifies mutations in the rpoB gene (coding for the [beta]-subunit of the RNA polymerase) for detection of RIF resistance, mutations in the katG gene (coding for the catalase peroxidase) for high-level INH resistance, and mutations in the promoter region of inhA gene (coding for the NADH enoyl
ACP reductase) for low-levels INH resistance.
If DST indicated isoniazid resistance, DNA sequencing of the catalase-peroxidase G (katG) and enoyl
reductase A (inhA) genes (19) was performed at the Public Health Research Institute Tuberculosis Center.
So I was able to start out with a virtual library of compounds that might be active against enoyl
reductase [a target for the development of anti-malarial agents].
33) This is particularly interesting in that dietary trans-fat is almost entirely consumed as singly unsaturated C18 FAs, whereas C18:2 isomers are, at least to some extent, interconverted by enoyl
isomerases, (22) and thus may reflect both nondietary and dietary constituents of the cell membrane FA content.
The activity of the enoyl
reductase enzyme in the PUFA gene cluster, pfaD, has also been measured in vitro (41).
ulcerans in invertebrates was based on detection of the enoyl
reduction domain (ER) in mlsA that encodes the lactone core of the mycolactone toxin, the major virulence determinant of M.
In addition, we found greater transcript levels in liver for all enzymes of butanoate metabolism (such as butyryl Coenzyme A synthetase 1, enoyl
Coenzyme A hydratase, hydroxyacyl-Coenzyme A dehydrogenase, and aldehyde dehydrogenase 1) as well as all five alcohol dehydrogenase (ADH) isoforms for metabolizing ethanol and retinol.
Studies of Toxoplasma gondii and Plasmodium falciparum enoyl
acyl carrier protein reductase and implications for the development of antiparasitc agents.