, fleroxacin, levofloxacin), others being employed in both human and veterinary medicine (Figure 1B-C) while some specific FQs are only for veterinary use (Figure 2A-C) .
The bioactive structures that some triazoles have displayed are comparable or even better than antibacterial and antifungal efficacy of reference drugs such as enoxacin
, chloromycin and fluconazole .
A randomized controlled trial (volunteer study) of sitafloxacin, enoxacin
, levofloxacin and sparfloxacin phototoxicity.
However, Trimethoprim and Ciprofloxacin were > 90%, Chloramphenicol >69%, and Gentamycin 61-67.3%, Streptomicin 61-73.07% and Oxytetracycline 69-71.15%, Enoxacin
45.07 and 53.84% and Amikacin 43.6 and 51.92 effective against MDR.
Exploring Mn-doped ZnS quantum dots for the room-temperature phosphorescence detection of enoxacin
in biological fluids.
NorA has more affinity to hydrophilic fluoroquinolones (ciprofloxacin, norfloxacin, enoxacin
) than hydrophobic compounds(sparfloxacin, trovafloxacin, levofloxacin) (7).
Salinas, "HPLC determination of enoxacin
, ciprofloxacin, norfloxacin and ofloxacin with photoinduced fluorimetric (PIF) detection and multiemission scanning: Application to urine and serum," Journal of Chromatography B, vol.
A specific example is enoxacin
, which by binding to TRBP (the human immunodeficiency virus-transactivating response RNA-binding protein) enhances the production of tumor suppressor miRNAs and inhibits tumor growth in a broad spectrum of cancer types .
Effects of epigallocatechin-gallate and enoxacin
on HeLa cells.
Several antibiotics and related drugs are associated with photosensitive reactions, e.g., amoxicillin, ciprofloxacin, clofazimine, dapsone, demeclocycline, doxycycline, enoxacin
, flucytosine, griseofulvin, lomefloxacin, minocycline, nalidixic acid, norfloxacin, ofloxacin, oxyfloxacin, oxytetracycline, pyrazinamide, sulfonamide, tetracycline, trimethoprim, etc.
They found that TARBP2 (TAR RNA-binding protein 2), which forms part of the Dicer-1 complex, was suppressed in [CD133.sup.+] Ewing sarcoma cells as well as [hpMSC.sup.EWS-FLI-1], and enoxacin
, which augments TARBP2 function, inhibited tumor growth through the restoration of miRNA maturation .
Quinolones (ciprofloxacin, levofloxacin, ofloxacin, norfloxacin, pefloxacin, enoxacin
, fleroxacin, lomefloxacin, and other new ones) have a favorable pharmacokinetic profile, with excellent oral bioavailability (greater than 95%) for most.