Pharmaleads present results of the first Dual ENKephalinase
Inhibitors (DENKIs) to reach the clinic
Neprilysin (NEP)  (neutral endopeptidase, enkephalinase
Racecadotril, an oral enkephalinase
inhibitor was used in the treatment of acute diarrhea by some researchers based on the principle that it prevents the degradation of endogenous opioids (Enkephalins) responsible for hypersecretion of water and electrolytes into intestinal lumen.
Indianapolis, IN) included amino acid precursors such as L-phenylalanine, l-tyrosine, L-tryptophan, 5-hydroxytryptophane, L-glutamine, a serotonin concentrating substance chromium, an enkephalinase
inhibitor D-phenylalanine, a neurotransmitter synthesis promoter vitamin B6, as well as both methionine and leucine.
It is thought that phenylalanine also serves to promote enkephalin activity, by acting as an enkephalinase
25 November 2011 - Pharmaleads, a French company developing small protease inhibiting molecules for diagnostic and therapeutic use, on Thursday announced positive data from two Phase I trials on PL37, its first molecule and lead compound of a new class of painkillers, Dual ENKephalinase
inhibition: a rational approach to antisecretory therapy for acute diarrhea.
inhibitor potentiates substance P- and electrically induced contraction in ferret trachea.
Use of D-phenylalanine, an enkephalinase
inhibitor, in the treatment of intractable pain," Adv Pain Res Ther, 5: 305-308, 1983.
It is Pharmaleads' first molecule and the lead compound of a new class of painkillers, Dual ENKephalinase
In this regard, Blum and colleagues (1987) reversed alcohol-seeking behavior in genetically preferring C57Bl/6J mice with the chronic administration of an enkephalinase
The angiotensin-converting enzyme inhibitor captopril inhibits proliferation of human ductal carcinoma cells in culture (31); in addition, angiotensin-converting enzyme and enkephalinase
activities have been detected in human breast cyst fluid (32).