The Company has demonstrated that, when transplanted into an animal model of hypomyelination (shiverer mouse), HuCNS-SC cells engraft
and differentiate into mature oligodendrocytes and form myelin sheaths around host nerve fibers.
However, despite the use of autologous cells, only a fraction of the LMSCs delivered to the lungs alveolar compartment appeared to engraft
Zeng said this is the first time iPSC-derived cells have been shown to engraft
and ameliorate behavioural deficits in animals with PD.
Within days, the sheets of cells permanently engraft
, attach to the healing connective tissue, and differentiate into normal epidermis.
These stem cells in their syringes are able to maintain their stem-ness and are able to engraft
at their organ specific sites once injected within 3 to 5 days from the date shipped.
Without it, the dose cannot be defined and the transplantation physician has no indication as to whether the product will engraft
in the patient.
However, if the implanted cells are too much like the cells of the targeted area they may not have the plasticity to engraft
and repair the injured tissue.
The Company's preclinical research has shown that HuCNS-SC cells can be directly transplanted; they engraft
, migrate, and differentiate into neurons and glial cells; and they survive for as long as one year with no sign of tumor formation or adverse effects.
The researchers injected hAECs into the animals' peritoneal cavity to see if the cells would migrate to the lung, engraft
, and form functional lung epithelium.
If donor human HSCs can be expanded in culture and engraft
non-matched or low-matched patients without graft-versus-host disease, this strategy will possibly lead to an ultimate solution to problems in allogeneic transplantation.
Enrollment is continuing under a modified protocol designed to increase the proportion of engineered stem cells that engraft
in the patient's bone marrow.
Researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft
and begin regenerating liver tissue in mice with chronic liver damage.