endotoxin-binding proteins

endotoxin-binding proteins

Blood proteins that bind to the dangerous endotoxin produced by GRAM NEGATIVE bacteria. Lipopolysaccharide binding protein (LBP) binds to a lipid component of bacterial endotoxin and delivers it to CD14 receptors on macrophages resulting in the release of inflammatory CYTOKINES. Another protein, the neutrophil granular protein bactericidal/ permeability-increasing protein (BPI) competes with LBP for toxin binding at the same site, blocks endotoxin delivery to macrophages and reduces the inflammatory response and the overall toxic effect.
References in periodicals archive ?
Okamoto et al., "Role of albumin and high-density lipoprotein as endotoxin-binding proteins in rats with acute and chronic alcohol loading," Alcoholism Clinical and Experimental Research, vol.
Are the serum levels of endotoxin-binding proteins reliable predictors of complications in the course of peritonitis?
and also contains transferrin, endotoxin-binding proteins and other acute phase proteins that can provide additional immune support benefits.