endotoxic shock


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endotoxic shock

Septic shock due to release of endotoxins by gram-negative bacteria. Endotoxins are lipopolysaccharides in the cell walls that are released during both reproduction and destruction of the bacteria. They are potent stimulators of inflammation, activating macrophages, B lymphocytes, and cytokines and producing vasodilation, increased capillary permeability, and activation of the complement and coagulation cascades. See: endotoxin; septic shock
See also: shock
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Two cases of torsion 360[degrees] died from a compromised uterus and endotoxic shock.
Zingarelli, "Parthenolide, an inhibitor of the nuclear factor-[kappa]B pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents," Molecular Pharmacology, vol.
Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Cardiovasc Res 2007; 76:132-140.
Cases include ectopic pregnancy, septic abortion, hypertensive emergencies, cardiac failure, acute asthma attack, fetal distress, jaundice, obstructed labor, postpartum collapse, acute pelvic inflammatory disease, ovarian torsion, endotoxic shock, acute urinary retention, sexual assault, abnormal uterine bleeding, emergency contraception, gynecologic oncology emergencies, postexposure prophylaxis to HIV and hepatitis B, cardiopulmonary resuscitation, diabetic ketoacidosis, and medicolegal and ethical issues.
On day 15 of the study, endotoxic shock was induced in LPS & CAPE+LPS groups with single IP injection of 20 mg/kg LPS (from Escherichea coli, Serotype O55:B5, Sigma-Aldrich) dissolved in PBS, and GalN (250 mg/kg).
Ergot alkaloids may lead to poor feathering and lesions forming on chickens, fescue foot in ruminants and shrunken udders in sows while endotoxins are responsible for endotoxic shock and death.
The research team investigated the role of H2S in endotoxic shock, which causes a fatal loss of blood pressure and extensive tissue inflammation.
Prof Burt said: "It is possible that he died as a consequence of endotoxic shock, secondary to a bowel infection but this cannot be confirmed."