endothelium-derived hyperpolarizing factor


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endothelium-derived hyperpolarizing factor

Abbreviation: EDHF
A vasodilating substance released by the vascular endothelium.
See: endothelium
See also: factor
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Joannides, "Role of endothelium-derived hyperpolarizing factor in the regulation of radial artery basal diameter and endothelium-dependent dilatation in vivo," Clinical and Experimental Pharmacology and Physiology, vol.
Hydrogen peroxide as an endothelium-derived hyperpolarizing factor. Pharmacol Res 2004; 49: 543-9.
On the other hand, etomidate (5-300 uM) inhibited the vasodilator response to endothelium-derived nitric oxide (EDNO) or endothelium-derived hyperpolarizing factor (EDHF) in isolated human renal arteries (15).
CYP2C9 is expressed in the endothelium and, via production of endothelium-derived hyperpolarizing factor (EDHF), may cause vasorelaxation as a result of hyperpolarization of vascular smooth muscle cells by activation of [Ca.sup.2+]-activated [K.sup.+] channels (6).