endothelium-derived

(redirected from endothelium-derived constricting factor)

endothelium-derived

derived from endothelium.

endothelium-derived vasoactive substances
substances produced by or released from endothelial cells which regulate vascular smooth muscle or other regulatory mechanism; include prostacyclin and other prostanoids, angiotensin, and relaxing or constricting factors.
endothelium-derived constricting factor
vasoconstrictive peptides isolated from vascular endothelial cells which are actively vasoconstrictive; endothelin (ET) is the most active of them.
endothelium-derived relaxing factor
several are known; nitrous oxide is one of the chief mediators, probably derived from l-arginine.
References in periodicals archive ?
With progressive dysfunction or injury, the endothelial cell supports increased vessel tone by the synthesis and release of the vasoconstrictor substances like endothelin and endothelium-derived constricting factor (s), and by reduced elaboration of vasodilator products.
The endothelium-derived constricting factors include a family of three endothelin isoforms (ET-1, ET-2, and ET-3) (55).
In addition, in the animal model of CB, the observed vasoconstriction could be explained also by a predominant action of endothelium-derived constricting factors.

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