Exercise and endothelial function: role of endothelium-derived
nitric oxide and oxidative stress in healthy subjects and hypertensive patients.
ECs play a central role in the regulation of vasomotor tone primarily by the production of Ca 2+-dependent vasodilator signals such as NO, prostaglandins, and endothelium-derived
However, the experiments performed to elucidate whether the endothelium-derived
hyperpolarizing factor EDHF could play a role in the vasorelaxant effect to clobenzorex, as previously reported for acetyl-choline (32,33), are discussed below.
We also aimed at investigating whether endothelium-derived
NO and antioxidative stress were involved in such effects.
NO, a kind of endogenous endothelium-derived
relaxing factor has been found having a vital role in the pathological and physiological process of many diseases.
The healthy endothelium, particularly endothelium-derived
nitric oxide, not only modulates the tone of underlying vascular smooth muscle but also inhibits several proatherogenic processes.
In severe cases, topical nitrate preparations have been used to mimic the vasodilatory and protective activity of endothelium-derived
To investigate the mechanisms involved in CGA-induced relaxation, the contribution of nitric oxide synthase (NOS), cyclooxy-genase (COX) and the endothelium-derived
hyperpolarizing factor (EDHF) was assessed in endothelium-intact aortic rings preincubated with the NOS inhibitor, N[omega]-nitro-L-arginine methyl ester (L-NAME, [10.
Vascular dysfunction is characterised by a reduced bioavailability of the endothelium-derived
molecule, nitric oxide (NO).
Isolated perfused rabbit coronary artery and aortic strip preparations: the role of endothelium-derived
2]S and NO act as endothelial derived hyperpolarizing factors or endothelium-derived
relaxing factors .
Causes of endothelial dysfunction in nitrate tolerant arteries are well studied, but little is known about mechanisms that underlie the responses to endothelium-derived
mediators in nitrate tolerant blood vessels.