endothelin-receptor antagonist


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endothelin-receptor antagonist

A medicine that lowers blood pressure by opposing the vasoconstricting effects of endothelins.
See also: antagonist

endothelin-receptor antagonist

Any drug that blocks the receptors for the artery-narrowing hormone ENDOTHELIN-1 and that can thus be used as a treatment for high blood pressure (HYPERTENSION). An example in BOSENTAN.
References in periodicals archive ?
Both bosentan and sitaxsentan are orally administered endothelin-receptor antagonists, but bosentan blocks both the "A" and "B" receptor subtypes, whereas sitaxsentan is highly selective for the A subtype.

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