EDNRA

(redirected from endothelin-1 receptor)

EDNRA

A gene on chromosome 4q31.22 that encodes endothelin-A receptor, a member of the endothelin receptor group of G-protein-coupled receptors, located primarily in the vascular endothelial cells where they play a role in vasoconstriction, vasodilation, bronchoconstriction and cell proliferation.

Molecular pathology
EDNRA polymorphisms have been linked to migraine headache resistance.
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Gorapa, "Influence of specific endothelin-1 receptor blockers on hemodynamic parameters and antioxidant status of plasma in LPS-induced endotoxemia," Pharmacological Reports, vol.
Medications that are commonly used for pulmonary hypertension such as endothelin-1 receptor inhibitors (bosentan) have also been effective in treating digital ischemia (a restriction in blood supply).
Endothelin-1 receptor antagonist BQ123 prevents pulmonary artery hypertension induced by low ambient temperature in broilers.

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