endothelin-1

EDN1

A gene on chromosome 6p24.1 that encodes endothelin 1, a potent vasoconstrictor of the endothelin family, which is produced by vascular endothelial cells.

endothelin-1

A peptide of 21 amino acids produced by the endothelial cells of arteries that has a powerful arterial tightening (vasoconstrictor) function. It also induces MITOSIS in cells. It has a short half-life of 1–2 minutes and its production is inhibited by endothelial-derived relaxing factor and stimulated by ANGIOTENSIN II, vasopressin, and thrombin.
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KEYWORDS: Osteoporosis, Insulin-like growth factor-1, Endothelin-1, Cytokines, Bone density.
Indeed, SILIDINE[R] induces the constriction of dilated microvessels by stimulating the synthesis of endothelin-1 protein.The activation of this metabolic pathway results in the contraction of the vascular smooth muscle cells.
Interstitial cells of Cajal (ICC), expression of stem cell factor (SCF), ghrelin, and endothelin-1 play important roles in intestinal motility (12-14).
Ultra V block (Histostain-Plus Kit, Invitrogen, Carlsbad, CA) was applied for 10 min prior to the application of the primary antibodies (Tumor Necrosis Factor -Alpha(TNF-[alpha])and Endothelin-1 antibodies, mouse monoclonal, 1/200, Santa Cruz Biotechnology) overnight.
Compared to placebo, a single CEB dose at baseline was associated with a significantly lower endothelin-1, elevated nitric oxide, and reduced:oxidised glutathione ratio, and an increased interferon-[gamma] level.
Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells.
Several studies have shown that endothelin-1 blood plasma concentration in T (Asn) allele carriers is higher than in subjects with GG (Lys/Lys) genotype [24, 25].
The levels of endothelin-1 (ET-1), a potent vasoconstrictor, have been shown to be increased in the plasma, sputum, and urine samples of COPD patients compared with those in controls [25, 26].
Baseline measurements at low altitude included venous blood analysis for hemoglobin, ferritin, pro-BNP, endothelin-1, pulmonary function testing using body-plethysmography, diffusion capacity for carbon monoxide, cycle ergometer exercise with capillary blood gas analysis, and echocardiography.
Blood concentrations of nitric oxide, endothelin-1 and endothelial nitric oxide synthase were measured on days 1-3 and 5-7 of the neonatal period.
Endothelial function assessment was performed by measurement of serum levels of endothelin-1, nitric oxide (NO) metabolites and lipid peroxidation products.
In vitro studies have shown that CathA has catalytic activity against several vasoactive peptides, including endothelin-1, angiotensin-1, and bradykinin, and some neuropeptides, such as oxytocin and substance P [5].

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