EDN1

(redirected from endothelin 1)

EDN1

A gene on chromosome 6p24.1 that encodes endothelin 1, a potent vasoconstrictor of the endothelin family, which is produced by vascular endothelial cells.
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References in periodicals archive ?
The density and distribution of endothelin 1 and endothelin receptor subtypes in normal and diabetic rat corpus cavernosum.
Gokdemir et al., "G-231A and G+70C polymorphisms of endothelin receptor type-A gene could affect the psoriasis area and severity index score and endothelin 1 levels," Indian Journal of Dermatology, vol.
Oruc et al., "The evaluation of endothelin 1 (EDN1) and endothelin receptor type A (EDNRA) gene polymorphisms in Hashimoto's thyroiditis," International Immunopharmacology, vol.
Design and synthesis of a specific endothelin 1 antagonist: effects on pulmonary vasoconstriction.
Harrison, "Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance," Proceedings of the National Academy of Sciences of the United States of America, vol.
Lindblom, "Contractile effects of endothelin 1 and endothelin 3 on myometrium and small intramyometrial arteries of pregnant women at term," Gynecologic and Obstetric Investigation, vol.
Serum levels of endothelin were determined by immunoradiometric assay (IRMA) (Nichol Institute Diagnostics, San Clemente, CA, USA) (10) using reagents from Amersham Biosciences (Endothelin 1 ELISA System, Buckinghamshire, UK).
A receptor shown in SEQ ID NO: 1 is an ET.sub.A-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1. A receptor shown in SEQ ID NO: 2 is an ET.sub.B-receptor which has an affinity for endothelins 1, 2 and 3 with no selectivity.
Phosphoramidon inhibits the intracellular conversion of big endothelin 1 to endothelin 1 in cultured endothelial cells.
Conversion of big endothelin 1 to 21-residue endothelin 1 is essential for expression of full vasoconstrictor activity: structure-activity relationships of big endothelin 1.
A previous study has demonstrated that endothelin 1 is involved in the development of cardiomyocyte hypertrophy (22), and the cell model of endothelin 1-induced cardiomyocyte hypertrophy had been reported in some experimental studies (23,24).

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