endothelin


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Related to endothelin: bradykinin, prostacyclin, endothelin 1

en·do·the·lin

(en'dō-thē'lin),
A 21-amino acid peptide originally derived from endothelial cells. It is an extremely potent vasoconstrictor. Three different gene products have been identified, endothelin 1, endothelin 2, and endothelin 3; they are found in brain, kidney, and endothelium (endothelin 1), intestine (endothelin 2), and intestine and adrenal gland (endothelin 3).

endothelin (ET)

[-thē′lin]
any of a group of vasoconstrictive peptides produced by endothelial cells. Three known endothelins, designated ET-1, ET-2, and ET-3, are chemically related to asp venom. ET-1 is the most potent vasoconstrictor yet discovered, being 10 times stronger than the second-most potent vasoconstrictor known, angiotensin II.

endothelin

powerful vasodilatory chemical, released by vascular endothelium

endothelin

see endothelium-derived constricting factor.
References in periodicals archive ?
Acet, "Selective endothelin a (ETA) receptor antagonist (BQ123) reduces both myocardial infarct size and oxidant injury," Toxicology, vol.
Endothelin and big endothelin in coronary heart disease and acute coronary syndromes.
Subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats.
Human pulmonary circulation is an important site for both clearance and production of endothelin in the anesthetized dog.
A second selective ETa endothelin receptor antagonist, ambrisentan, was evaluated in a doubleblind, dose-ranging study that included 64 adult patients with PAH.
Acute endothelin A receptor antagonism improves pulmonary arterial hypertension that is primary or autoimmune and related to congenital heart disease.
Measurement of bigET-1, which has slower clearance (14), has been proposed as an alternative approach for estimation of ET-1 release, but alterations in plasma bigET-1 may also not reflect changes in ET-1 synthesis because bigET-1 is cleaved at the tissue level not only into active ET-1, but also into the 31-amino acid endothelin peptide ET-[1.
According to the research, since the overproduction of melanine is induced by endothelin and SCF even if the skin is no longer exposed to ultraviolet rays, skin flecks tend to be persistent.
Based on those results and results of the associated extension study, Myogen believes ambrisentan's profile may position it as the best-in-class endothelin receptor antagonist with demonstrated:
TracleerTM, the first orally available dual endothelin receptor antagonist, is already approved and available in major markets worldwide for the treatment of pulmonary arterial hypertension (PAH), a chronic life-threatening condition that severely compromises the function of the lungs and heart.
In the recent study, polyphenols inhibited production of endothelin 1--a substance that stimulates hardening of the arteries.

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