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An endogenously produced antiangiogenic protein, a proteolytic fragment of collagen XVIII, that inhibits endothelial cell proliferation, angiogenesis and tumor growth, and stimulates endothelial apoptotic cell death. The proapoptoic activity appears to be mediated through tyrosine kinase signaling and a reduction of the antiapoptoic proteins Bcl-2 and Bcl-XL.
[endo- + G. statos, stalled, arrested, + -in]
Farlex Partner Medical Dictionary © Farlex 2012
A potent, naturally occurring antiangiogenic protein that inhibits the formation of the blood vessels that feed tumors. It is under investigation as a potential cancer therapy.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
A protein fragment of collagen that contributes to the regulation of blood vessel growth. It is being investigated for its potential to shrink malignant tumors by decreasing their blood supply.
Medical Dictionary, © 2009 Farlex and Partners
endostatinA substance that interferes with the development of the lining of blood vessels (endothelium). Since cancers require blood vessels to grow and tumour endothelium divides up to 50 times faster than normal endothelium, this substance offers promise as an anticancer drug. Trials in mice have been remarkably promising and human trials are under way. See also ANGIOSTATIN.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005