endostatin


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endostatin

(en'dō-stat-in),
An endogenously produced antiangiogenic protein, a proteolytic fragment of collagen XVIII, that inhibits endothelial cell proliferation, angiogenesis and tumor growth, and stimulates endothelial apoptotic cell death. The proapoptoic activity appears to be mediated through tyrosine kinase signaling and a reduction of the antiapoptoic proteins Bcl-2 and Bcl-XL.
[endo- + G. statos, stalled, arrested, + -in]
Farlex Partner Medical Dictionary © Farlex 2012

endostatin

(ĕn′dō-stăt′n)
n.
A potent, naturally occurring antiangiogenic protein that inhibits the formation of the blood vessels that feed tumors. It is under investigation as a potential cancer therapy.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

endostatin

(ĕn″dŏ-stăt′ĭn)
A protein fragment of collagen that contributes to the regulation of blood vessel growth. It is being investigated for its potential to shrink malignant tumors by decreasing their blood supply.
Medical Dictionary, © 2009 Farlex and Partners

endostatin

A substance that interferes with the development of the lining of blood vessels (endothelium). Since cancers require blood vessels to grow and tumour endothelium divides up to 50 times faster than normal endothelium, this substance offers promise as an anticancer drug. Trials in mice have been remarkably promising and human trials are under way. See also ANGIOSTATIN.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The "Investigation Report on China's Recombinant Human Endostatin Market, 2019-2023" report has been added to ResearchAndMarkets.com's offering.
Osterhus, "Serum levels of angioregulatory mediators in healthy individuals depend on age and physical activity: studies of angiogenin, basic fibroblast growth factor, leptin and endostatin," Scandinavian Journal of Clinical and Laboratory Investigation, vol.
The stored plasma samples were assayed for multiple inflammatory and immune proteins (interleukin (IL)-6, complements C3a and C5a, matrix metalloproteinase (MMP)-9, macrophage colony-stimulating factor (M-CSF), and endostatin).
Saishin et al., "Intraocular expression of endostatin reduces VEGF-induced retinal vascular permeability, neovascularization, and retinal detachment," The FASEB Journal, vol.
Serum levels of endostatin and matix metalloproteinase-9 associated with high stage and grade primary transitional cell carcinoma of the bladder.
Endostatin is a proteolytic C-terminal fragment of collagen XVIII with a molecular weight of 20 kDa.
It is interesting to note that some collagen derivatives such as tumstatin (cleavage product of collagen IV) and endostatin (cleavage product of collagen XVIII) have been reported to prevent neovascularization in streptozotocin-induced diabetic mice by inhibiting some angiogenic factors including VEGF and suppressed glomerular hypertrophy, hyperfiltration, and albuminuria [245, 246].
This was the first report of the efficacy of Endostar, a recently introduced recombinant human endostatin, considered to be a valuable antiangiogenic agent.
(1) Inhibits the migration and/or proliferation of endothelial cells: chondromodulin-I (ChM-I) [64]; pigment epithelium-derived factor (PEDF) [65]; vasostatin [66]; antiangiogenic matricryptins derived of type IV collagen, including arresten, canstatin, and tumstatin [67-69]; tissue inhibitor of matrix metalloproteinase (TIMP) inhibits extracellular matrix degradation and remodeling which is necessary for efficient endothelial cells migration and proliferation [70, 71]; endostatin, was found to inhibit the migration, but not the proliferation, of endothelial cells in vitro and disrupt tumor vascularization and growth in mice [72]; thrombospondin-1 inhibits angiogenesis through direct effects on endothelial migration and survival through indirect effects on growth factor mobilization [73]
Recombinant human endostatin (rh-endostatin, endostar) is a Chinese broad spectrum humanized antiangiogenic drug that targets vascular endothelial cells, but not tumor cells.
Nouso et al., "Altered expression of vascular endothelial growth factor, fibroblast growth factor-2 and endostatin in patients with hepatocellular carcinoma," Journal of Gastroenterology and Hepatology, vol.