Endorphinergic neurons originating in the arcuate hypothalamic nucleus move towards other hypothalamic nuclei of the septum and the accumbens nucleus (important centers mediating the positive reinforcement and reward effects of many addictive drugs) and towards periaqueductal grey matter, amygdala and hypothalamus (Wise & Bozarth, 1982).
This preference, genetically determined and related to the the endorphinergic system, seems to be confirmed with respect to the sensitivity of the encephalinergic system to alcohol (Li, Li & Froehlic, 1992).
mechanisms in food, salt and water intake: an overview.
Genetic variables could include serotonergic genes (serotonergic receptors [5HT2a]; serotonin transporter 5HTlPR); endorphinergic
genes (mu OPRM1 gene; proenkephalin [PENK, PENK polymorphic 3' UTR dinucleotide (CA) repeats]; GABergic gene (GABRB3), and dopaminergic genes (ANKKI Taq A; DRD2 C957T, DRD4 7R, COMT Val/met substation; MAO-A uVNTR; and SLC6A3 9 or 10R).
Need of supporting and recognition has been related to endorphinergic
, oxytocin and vasopressin systems.
dysregulation is related to the coping style.
These studies hint that activity generated mood changes are mediated, at least in part, through endorphinergic
modulation of acceptability of putative reinforcers.
It is also known that deficiencies in endorphinergic
pathways influence one's immune response, which induces abnormalities in a number of aproimetric parameters (Li et al.