Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
one of a group of opiate-like peptides produced naturally by the body at neural synapses at various points in the central nervous system pathways, where they modulate the transmission of pain perceptions. The term endorphin was coined by combining the words endogenous and morphine. Like morphine, endorphins raise the pain threshold and produce sedation and euphoria; the effects are blocked by naloxone, a narcotic antagonist.
Any of a group of peptide hormones that bind to opioid receptors and act as neurotransmitters. Endorphins reduce the sensation of pain and affect emotions.
endorphinPhysiology An endogenous opioid–eg, endorphin, leu-enkephalin, met-enkephalin, dynorphin; each binds to a cognate receptor; endorphins act as neurotransmitters and neuromodulators, they are concentrated in the brain and associated with analgesia. See Enkephalin, Neuropeptide, Neurotransmitter, POMC.
A natural substance produced in the brain that binds to opioid receptors, thus dulling the perception of pain; postulated to trigger "exercise high," a state of euphoria and exhilaration during intense exercise.