endoperoxide


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en·do·per·ox·ide

(en'dō-pĕr-ok'sīd),
A peroxide (-O-O-) group that bridges two atoms that are both parts of a larger molecule.
References in periodicals archive ?
Here, we report the susceptibility profile of F32-ART5 parasites selected after 5 years of escalating artemisinin pressure and assess their susceptibility to this drug and other endoperoxides, as well as unrelated molecules from different chemical classes that inhibit distinct parasite metabolic pathways.
Schmaussmann A, Peskar BM, Stettler C, et al: Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastrointestinal ulcer models in rats.
The conversion of arachidonic acid (20:4) to cyclic endoperoxide ([PGG.
Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite.
The effect of the molecule, which not only targets malaria but possibly also other infections and even breast cancer, is due to, among other things, a very reactive chemical group formed by two neighbouring oxygen atoms - which chemists refer to as an endoperoxide.
The limiting factors in uterine epithelia controlling PGF secretion are the availability of arachidonic acid and the rate of PGF synthesis by prostaglandin endoperoxide H synthase (PTGS2).
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isoenzymes by aspirin and other non-steroidal anti-inflammatory drugs.
Alterations in cellular adhesion and apoptosis in epithelial cells overexpression prostaglandin endoperoxide synthase-2.
Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo.
In addition, endoperoxide intermediates can rearrange in vivo to form other types of Isoprostanes (5-7) or highly reactive [gamma]-ketoaldehydes (8).
Artemisinin (qinghaosu), a sesquiterpene endoperoxide isolated from the Chinese traditional herb Artemisia annua, is a widely used drug targeting the malaria pathogen Plasmodium falciparum (Miller and Su 2011).