endonuclease


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endonuclease

 [en″do-noo´kle-ās]
an enzyme that cleaves internal bonds of polynucleotides.
restriction e's enzymes that cleave large DNA molecules at specific sequences of four to six nucleotides. See also recombinant dna technology.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

en·do·nu·cle·ase

(en'dō-nū'klē-ās),
An enzyme (phosphodiesterase) that cleaves the internal phosphodiester bonds in a DNA molecule, thus producing DNA fragments of varying size. Compare: exonuclease.
Farlex Partner Medical Dictionary © Farlex 2012

endonuclease

(ĕn′dō-no͞o′klē-ās′, -āz′, -nyo͞o′-)
n.
Any of a group of enzymes that catalyze the hydrolysis of bonds between nucleotides in the interior of a DNA or RNA molecule.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

en·do·nu·cle·ase

(en'dō-nū'klē-ās)
A nuclease (phosphodiesterase) that cleaves polynucleotides (nucleic acids) at interior bonds, thus producing polynucleotide or oligonucleotide fragments of varying size.
Compare: exonuclease
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

endonuclease

a NUCLEASE that cleaves PHOSPHODIESTER BONDS from within nucleic acid molecules. See also RESTRICTION ENDONUCLEASE, compare EXONUCLEASE.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

en·do·nu·cle·ase

(en'dō-nū'klē-ās)
A nuclease (phosphodiesterase) that cleaves polynucleotides (nucleic acids) at interior bonds.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
Chandrasegaran, "Functional domains in Fok I restriction endonuclease," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
[9] Jinek, M., et al., A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Ultrasensitive DNA detection by cascade enzymatic signal amplification based on Afu flap endonuclease coupled with nicking endonuclease.
Unlike the chimeric TALEN proteins, target site recognition by CRISPR/Cas9 system is accomplished by the complementary sequence based interaction between the guide (noncoding) RNA and DNA of the target site and the guide RNA and Cas protein complex has the nuclease activity for exact cleavage of double-stranded DNA using Cas9 endonuclease (Table 1) [9, 24, 67].
Barth et al., "tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia," Nature Genetics, vol.
Genomewide binding of the CRISPR endonuclease Cas9 in mammalian cells.
Fragments obtained after endonuclease digestion were separated by electrophoresis on 3% agarose gel (Agarose MS, Roche(r), Germany) containing ethidium bromide in TBE buffer for about 90 min at 90V in the presence of the pUC19/MspI fragment size marker so as to determine the genotypes of individual specimens.
Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia.
For other authors, DNases involved in apoptosis may be classified into three groups: the [Ca.sup.2+] / [Mg.sup.2+] endonucleases, the [Mg.sup.2+] endonuclease, and the cation-independent endonucleases [33].
Then 12 microliters of the amplified fragment (range 173-208 bp depending on HPV type) were used in two different restriction reactions with endonucleases Rsal and Tru91, respectively, and analyzed using a capillary electrophoresis system.
Burt's notion was to domesticate a microbial family of selfish elements called homing endonuclease genes.