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an enzyme that cleaves internal bonds of polynucleotides.
restriction e's enzymes that cleave large DNA molecules at specific sequences of four to six nucleotides. See also recombinant dna technology.
An enzyme (phosphodiesterase) that cleaves the internal phosphodiester bonds in a DNA molecule, thus producing DNA fragments of varying size. Compare: exonuclease.
endonuclease/en·do·nu·cle·ase/ (-noo´kle-ās) any nuclease specifically catalyzing the hydrolysis of interior bonds of ribonucleotide or deoxyribonucleotide chains.
restriction endonuclease an endonuclease that hydrolyzes DNA, cleaving it at an individual site of a specific base pattern.
endonuclease(ĕn′dō-no͞o′klē-ās′, -āz′, -nyo͞o′-)
Any of a group of enzymes that catalyze the hydrolysis of bonds between nucleotides in the interior of a DNA or RNA molecule.
an enzyme that cleaves or hydrolyzes phosphodiester bonds within a polynucleotide chain. Compare exonuclease.
A nuclease (phosphodiesterase) that cleaves polynucleotides (nucleic acids) at interior bonds, thus producing polynucleotide or oligonucleotide fragments of varying size.
endonucleasea NUCLEASE that cleaves PHOSPHODIESTER BONDS from within nucleic acid molecules. See also RESTRICTION ENDONUCLEASE, compare EXONUCLEASE.
A nuclease (phosphodiesterase) that cleaves polynucleotides (nucleic acids) at interior bonds.
a nuclease that cleaves internal bonds of polynucleotides.