Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
an enzyme that cleaves internal bonds of polynucleotides.
restriction e's enzymes that cleave large DNA molecules at specific sequences of four to six nucleotides. See also recombinant dna technology.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
An enzyme (phosphodiesterase) that cleaves the internal phosphodiester bonds in a DNA molecule, thus producing DNA fragments of varying size. Compare: exonuclease.
Farlex Partner Medical Dictionary © Farlex 2012
endonuclease(ĕn′dō-no͞o′klē-ās′, -āz′, -nyo͞o′-)
Any of a group of enzymes that catalyze the hydrolysis of bonds between nucleotides in the interior of a DNA or RNA molecule.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
A nuclease (phosphodiesterase) that cleaves polynucleotides (nucleic acids) at interior bonds, thus producing polynucleotide or oligonucleotide fragments of varying size.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
endonucleasea NUCLEASE that cleaves PHOSPHODIESTER BONDS from within nucleic acid molecules. See also RESTRICTION ENDONUCLEASE, compare EXONUCLEASE.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
A nuclease (phosphodiesterase) that cleaves polynucleotides (nucleic acids) at interior bonds.
Medical Dictionary for the Dental Professions © Farlex 2012