Correlation between tissue transglutaminase antibodies and endomysium
antibodies as diagnostic markers of coeliac disease.
12] Nonstandard abbreviations: CD, celiac disease; tTG, tissue transglutaminase; EmA, endomysium
antibodies; anti-tTG, antibodies against tTG; sIgAD, selective IgA deficiency; anti-dGli, antibodies against deamidated gliadin.
The most sensitive antibody tests detect IgA-class antibodies against tissue transglutaminase (tTGA) and endomysium
What happens to patients with positive tissue transglutaminase and endomysium
antibody results in general practice.
Tests most commonly offered by commercial laboratories include immunoglobulin IgG- and IgA-based antigliadin antibodies (AGA IgG and AGA IgA); IgA endomysium
antibody (EMA IgA); IgA tissue transglutaminase antibody (TG IgA); IgA antireticulin antibody; and anti-actin antibody.
1-3) The pathogenesis involves a T-cell-mediated immune response and autoreactive B lymphocytes that produce autoantibodies directed against gliadin, endomysium
, or tissue transglutaminase in individuals with a genetic susceptibility related to human leukocyte antigens HLA-DQ2 and HLA-DQ8.
The diagnosis of celiac disease was based on small-bowel biopsy showing severe villous atrophy with crypt hyperplasia (Marsh type III lesions) (15) and increased serum levels of antibodies to TG and/or endomysium
Predictive value for coeliac disease of antibodies to gliadin, endomysium
, and jejunum in patients attending for jejunal biopsy.
IgA class endomysium
antibodies in dermatitis herpetiformis and coeliac disease.
Antibodies against human tissue-transglutaminase and endomysium
in diagnosing and monitoring coeliac disease.
Pretreatment of CD sera with tTG eliminated the endomysial staining pattern in human umbilical cord, suggesting that tTG could be the previously unknown endomysium