Investigators have found that up to a 10% serous component within an endometrioid tumor
can confer a worse prognosis and likely warrants more aggressive treatment (Cancer 2004;101:2214-21).
Compared with the other 2 groups, the MLH1 methylated group was associated with a higher-grade endometrioid tumor
with lymphovascular invasion, and 19% had the distinctive undifferentiated histology.
For the purpose of our study, if notable nuclear atypia was present and was seen in an arbitrarily set proportion of less than 10% of an endometrioid tumor
, then reviewers classified the case as G2EC with focal, marked nuclear atypia.
Soslow, MD, written communication, 2013), alerting the clinician that the tumor may be a variant endometrioid tumor
with loss of p53 function.
Gly-to-Asp (GGT [right arrow] GAT) mutations at codon 12 of the K-ras gene were common for two borderline tumors (one mucinous and one serous), two mucinous ovarian carcinomas, one clear cell neoplasm, one endometrioid tumor
, and one nonepithelial tumor, but not for the serous ovarian carcinomas.
The reported degree of immunoreactivity in FIGO 3 endometrioid tumor
is markedly less, ranging from 15% to 50%.
Morules with optically clear nuclei in ovarian borderline endometrioid tumor
Specifically, each endometrioid tumor
was annotated with information on the mutational status of genes previously shown to be frequently altered in both ovarian and endometrial endometrioid adenocarcinomas.
While most low-grade endometrioid endometrial tumors are not associated with p53 mutations, a significant subset of high-grade endometrioid tumors
are; thus, any ancillary testing for the presence of a p53 mutation should be performed with an awareness of the limitations of the result with respect to providing a conclusive answer as to exact tumor type.
In addition, while the FIRES trial included women with high-risk histologies, the majority of patients had low-risk, endometrioid tumors
are predominantly solid, with a quarter being bilateral and associated with an endometrial carcinoma.
Likewise, age at menopause, endometriosis, and tubal ligation were associated only with clear cell and endometrioid tumors
," the researchers wrote.