endometrial hyperplasia


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endometrial hyperplasia

increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.

endometrial hyperplasia

an abnormal condition characterized by overgrowth of the endometrium resulting from sustained stimulation by estrogen (of endogenous or exogenous origin) that is not opposed by progesterone. Estrogen acts as a growth hormone for the endometrium. Through a complex intercellular mechanism, endometrial cells bind estrogen preferentially and undergo changes characteristic of the proliferative phase of the menstrual cycle. If estrogen stimulation continues for 3 to 6 months without periodic cessation or counteractive progesterone stimulation, as occurs in anovulatory or perimenopausal women and in those receiving replacement estrogen without added progestogen, the endometrium becomes abnormally thickened and glandularized. Unremitting estrogen stimulation eventually causes cystic or adenomatous endometrial hyperplasia. The latter is a premalignant lesion that undergoes malignant degeneration in approximately 25% of cases. The causative relationship between estrogen and endometrial hyperplasia is well established; there is some indication but no proof that estrogen also provokes the change from hyperplasia to neoplasia and malignancy. Endometrial hyperplasia often results in abnormal uterine bleeding. Such bleeding, particularly in older women, constitutes an indication for biopsy or curettage of the endometrium to establish histopathological diagnosis and to rule out malignancy. A functioning estrogen-secreting tumor is suspected if the woman is not taking estrogen medication. Progestogen therapy is effective in reversing the abnormal histopathological changes of endometrial hyperplasia. If hyperplasia is adenomatous, hysterectomy is commonly performed.

endometrial hyperplasia

Adenomatous hyperplasia of endometrium Gynecology A premalignant endometrial lesion of older ♀
Endometrial hyperplasia
Hyperplasia without atypia Glands are crowded w/o cytologic atypia; these have a < 2% progress to carcinoma
Simple hyperplasia Glands are not back-to-back
Complex hyperplasia Glands are back-to-back
Hyperplasia with atypia Glands are crowded with cytologic atypia; ± 23% progress to carcinoma

en·do·me·tri·al hy·per·pla·si·a

(en'dō-mē'trē-ăl hī'pĕr-plā'zē-ă)
Increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.
References in periodicals archive ?
Adding to the already robust reimbursement for saline-infused sonogram (especially 3-D) used in the diagnosis of abnormal uterine bleeding, endometrial polyps, retained products of conception and endometrial hyperplasia, hysteroscopic diagnosis and treatment offers overall very favorable compensation when performed in an in-office setting.
Benign lesions presented in combination with each other predominantly endometrial hyperplasia, polyp, prolapsed uterus, fibroid, erosion of cervix, cervical dysplasia.
According to the company, the submission includes a comprehensive, systematic review of the medical literature on the use of vaginal estrogen products and the risk of endometrial hyperplasia or cancer, including the safety data from the recently published Women's Health Initiative Observational Study of vaginal estrogen use in postmenopausal women and information on the relevance of the first uterine pass effect for low-dose vaginal estrogen products.
The most common pathology observed in the study was endometrial hyperplasia in 392 (25.
The safety cohort included all women who took at least one capsule of the study drug, whose vasomotor severity did not qualify them for the efficacy substudy, tracking the incidence of endometrial hyperplasia out to 1 year for those who participated in the extended safety portion and the incidence of other adverse and serious adverse events.
As we move toward a value-based health care model, study data indicate that we consider obesity over age as a risk factor for endometrial hyperplasia, the LNG-IUD for treatment of heavy bleeding in obese patients, and diagnostic hysteroscopy in the office versus the operating room
Objective: To determine the frequency of endometrial hyperplasia in histopathology of endometrial curettings in perimenopausal women with abnormal uterine bleeding.
Among them, 29 cases were atypical endometrial hyperplasia (11 cases) or carcinoma (18 cases) confirmed by histology evaluation.
In infertile women various types of endometrial hyperplasia are not commonly found which is also reflected in our study as simple hyperplasia in 1.
Evidence from two new studies from the Perelman School of Medicine at the University of Pennsylvania suggest that metformin improves survival for some breast cancer patients and shows promise as a treatment for patients diagnosed with endometrial hyperplasia.
The most common organic causes for abnormal uterine bleeding include endometrial polyps, uterus leiomyomas, endometrial hyperplasia and endometrium cancer.