Staphefekt is billed the first
endolysin registered for use on the skin's microbiome, and is currently used as the active compound in Gladskin (a range of topical creams and gels for inflammatory skin conditions, such as eczema).
coli enabled the investigators to produce the
endolysin protein and assess its ability to control levels of C.
Assessment of in vivo anti-staphylococcal activity of the LysSA1
endolysin in septic mice model.
It uses a "designer"
endolysin, Staphefekt, which the scientists engineered to latch on to the surface of bacteria cells and tear them apart.
The discovery also indicated that all the phases carried a gene coding a protein called
endolysin, an enzyme that breaks down bacterial cell walls.
Hatfull and his colleagues also found that the 11 viruses they studied carry a gene for the enzyme
endolysin, which can degrade bacterial cell walls.
coli enabled the investigators to produce the
endolysin protein so that they could assess its ability to control levels of C.
The phages have a secret weapon - an enzyme that can destroy the wall from inside, thus called
endolysin.
Endolysin of bacteriophage BFK2O: evidence of a catalytic and a cell wall binding domain.
All carry a gene that makes a protein called
endolysin - an enzyme thought to destroy bacteria by breaking down their cell walls.
They also determined the gene coding for the phage
endolysin that's responsible for degrading cell walls before the release of certain virus particles known as virions.
The researchers are expressing the
endolysin in Lactococcus lactis, the bacterium involved in the cheese fermentation process.
