Soluble fms-Like Tyrosine Kinase 1 (sFlt1), Endoglin
and Placental Growth Factor (PlGF) in Preeclampsia among High Risk Pregnancies.
Wiercinska et al., "Matrix metalloproteinase-14 (MT1-MMP)-mediated endoglin
shedding inhibits tumor angiogenesis," Cancer Research, vol.
(CD105) as a urinary and serum marker of prostate cancer.
Pulmonary arterial hypertension 1.1 Idiopathic 1.2 Heritable 1.2.1 BMPR2 1.2.2 ALK-1, endoglin
(ENG) (with or without hereditary hemorrhagic telangiectasia 1.2.3 Unknown 1.3 Drug and toxin induced 1.4 Associated with: 1.4.1 Connective tissue disease 1.4.2 Human immunodeficiency virus infection 1.4.3 Portal hypertension 1.4.4 Congenital heart disease 1.4.5 Schistosomiasis 1.4.5 Chronic hemolytic anemia 1.5 Persistent pulmonary hypertension of the newborn 1' (b) Pulmonary veno-occlusive disease and/or pulmonary capillary hemangiomatosis 2.
MiR-208 induces myocardial fibrosis by upregulating the expression of endoglin
, a coreceptor of TGF and [beta]-myosin heavy chain ([beta]-MHC) [68, 69].
The prevalence rate in all races suggested in some population studies is 1 in 10,000, and 2 mutations have been identified, occurring in 85% of cases: type 1 is related to a mutation in the endoglin
gene (ENG, chromosome 9q34.1), and type 2 is related to a mutation in the activin receptor-like kinase 1 gene (ACVRL 1, ALK1, chromosome 12q31.34), with a mild phenotype and late onset .
Ward et al., "CD105 (Endoglin
) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma," Acta Neuropathologica, vol.
Joseph, "Transforming growth factor beta receptor endoglin
is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II," Circulation Research, vol.
Sheibani, "PECAM-1 isoforms, eNOS and endoglin
axis in regulation of angiogenesis," Clinical Science, vol.
Another molecule which has been implicated in the regulation of endothelial function is endoglin
, a 180 Kda homodimeric integral membrane glycoprotein serving as a receptor for the transforming growth factor-[beta] (TGF-[beta]) superfamily (5,6,7,8).
* Endothelial dysfunctions due to decreased VEGF and PDGF and soluble endoglin
decrease nitric oxide department vasodilation.
The abnormal vascular structures in HHT were found to result from mutations in the transforming growth factor6/bone morphogenetic protein signaling pathway genes endoglin
[5, 6] and activin type-II-like receptor kinase 1 .