He previously suffered an ischemic stroke, non-ST elevation myocardial infarction with percutaneous coronary intervention of the right coronary artery, had an implanted cardiac pacemaker because of sick sinus syndrome, increased blood levels of creatinine (116 [micro]mol/L) and endogenous creatinine clearance
(78.6 mL/min/1.73 [m.sup.2]) with proteinuria (454 mg/24 h), without ophthalmological and dermatological manifestations of the disease.
However, in moderate to severe renal insufficiency, GFR values calculated from the endogenous creatinine clearance
are significantly overestimated, since creatinine is secreted by the proximal tubule in the settings of renal failure and uremia [5, 6].
Gross, "Is endogenous creatinine clearance
still a reliable index of glomerular filtration rate in diabetic patients?" Braz J Med Biol Res, vol.
The endogenous creatinine clearance
(Cr.CL) in milliliter per minute estimates the glomerular filtration rate.
The twenty-four hourly endogenous creatinine clearance
as a clinical measure of the functional state of the kidneys.