Because 1 [micro]M RAP fully, but selectively, inhibits binding of DBP to megalin and the megalin-dependent co-receptor cubilin (Niemeier et al., 1999; Rowling et al., 2006), other non-receptor mediated endocytotic
processes, as well as passive diffusion across the PTEC apical membranes, may account for the residual uptake of 25O[HD.sub.3] into the PTECs observed during RAP co-administration.
(2016) Distinct modes of endocytotic
presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice.
An improved understanding of cholesterol and sugar homeostasis has tremendous potential for improving general public health, and furthermore this proposal will help to uncover general principles of endocytotic
uptake and facilitated diffusion systems at the molecular level.
uptake of iron oxide nanoparticles by cultured brain microglial cells, Acta Biomater, 9(9): 8454-65 (2013).
Fiorucci et al., "HIV-1 Nef induces the release of inflammatory factors from human monocyte/macrophages: involvement of Nef endocytotic
signals and NF-[kappa]B activation," Journal of Immunology, vol.
Syono, "Two ineffective-nodulating mutants of Lotus japonicus--different phenotypes caused by the blockage of endocytotic
bacterial release and nodule maturation," Plant & Cell Physiology, vol.
In polarised epithelial cells, for example, Myo6(-LI) has been shown to associate with uncoated endocytotic
vesicles via GIPC1, while Myo6(+LI) is recruited to clathrin coated pits/vesicles via Dab2 .
A report by Perez-Otano et al.,  in 2006 was the first to highlight the activity dependent interaction of PACSIN1/syndapin, an endocytotic
adaptor protein, with GluN3A .
That the character of cargo predetermines the endocytotic
uptake and the influence on signal transduction  might explain the differences in the influence on MAPK phosphorylation.
Such changes point to a toxic effect of VCR on these cell types, suggesting impairment of epididymal function, particularly concerning to sperm maturation and endocytotic
removal of the contents of the cytoplasmic droplets and dead sperm.
In addition, the nucleus of the ciliated cell is frequently displaced in apical cytoplasm (Figure 3D), and reduced frequencies of endocytotic
vesicles and lysosomal granules are found in the ciliated cell (Figure 3E).
The complexes are taken up by directly penetrating the cell membrane or by an endocytotic