endocrine disruptor


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endocrine disruptor

A substance which interferes with the synthesis, secretion, transport, binding, action or elimination of natural hormones in the body that are responsible for development, behaviour, fertility and maintenance of homeostasis (normal cell metabolism).

Examples
DDT, polychlorinated biphenyls, bisphenol A, polybrominated diphenyl ethers, phthalates.

endocrine disruptor

(dĭs-rŭp′tĕr)
A chemical that may imitate or block the function of natural hormones if it is absorbed by the body. Many pesticides and plasticizing compounds, e.g., phthalates, are thought to disrupt endocrine pathways, esp. if they are absorbed by pregnant women during embryonic and fetal development.
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References in periodicals archive ?
Endocrine disruptors can also affect the nervous system via receptors expressed on neuroendocrine cells.
"You don't need a lot of something acting like testosterone or estrogen to mess things up, especially in something as vulnerable as a developing fetus" says Laurel Standley, a chemical researcher who studies endocrine disruptors.
Those lab studies that have red-flagged BPA suggest that the effects of endocrine disruptors can be seen with levels of exposure as low as two micrograms (meg) per kg of body weight, considerably lower than the FDA's proposed safe level.
From animal studies, researchers have learned much about the mechanisms through which endocrine disruptors influence the endocrine system and alter hormonal functions.
EPA's proposed Endocrine Disruptor Screening Program substantially reflects the EDSTAC recommendations.(114) Particularly, EPA agreed to expand the scope of the testing program beyond the FQPA and SDWA provisions to include a wide range of chemicals to which Americans are exposed.(115) After initial screening and priority setting, EPA plans to promulgate its first test orders under its FQPA and SWDA authority in late 2001.(116) Additionally, "EPA may propose a TSCA test rule to require screening of chemicals that may not be covered by the FFDCA/SDWA.
Although the term "endocrine disruptor" was not yet in use, Theo's descriptions mirrored what we now recognize as characteristics of endocrine disruptor exposures.
But a recent study from Silent Spring Institute in Massachusetts (silentspring.org) shows we can drastically reduce our consumption of the endocrine disruptors bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) by making a few basic changes in our dietary practices.
Endocrine disruptor. According to Centers for Disease Control and Prevention (CDC) figures, 93 percent of Americans have traces of BPA in their urine.
Washington, Nov 08 ( ANI ): While traditional toxicology studies have indicated that only very high doses of Bisphenol A (BPA)- known endocrine disruptor that hijacks the normal responses of hormones- affect exposed animals, a new study has revealed that the lower doses of the chemical may also affect humans.
The opinion emphasises that a single test is not sufficient to decide whether a substance is an endocrine disruptor, and recommends carrying out several tests, which should then be "assessed together by experts in a weight-of-evidence approach".
At issue is EPA's Endocrine Disruptor Screening Program (EDSP) which requires pesticide and other chemical manufacturers to test their products for adverse effects on the human endocrine system.