K+ cycling and the endocochlear potential
. Hear Res 2002; 165: 1-9.
 It is believed that mutations in GJB2 (connexin 26 gene) affect its ability to transport potassium ions and therefore regulate the endocochlear potential
required for nerve impulses involved in hearing, but the mode of action is not definitively elucidated.
(10) Prolonged latency of wave V with normal IPL would suggest involvement of cochlear nerve or the cochlea which may be due to depression of endocochlear potential
as a result of hypoxia and acidosis.
In typical high-frequency sensorineural hearing loss, the damage occurs primarily in the basal end of the cochlea, either to the hair cells themselves, or in the case of aging, apparently also to the endocochlear potential
that serves to depolarize the hair cells when they are stimulated by sound .
The cochlear endolymph has a distinctively high concentration of K+ (150 mM) and a positive potential of 80 mV referred to as the endocochlear potential
, which is meticulously maintained and indispensable to cause depolarization of hair cells.
 They discovered that even a small amount of air in the scala vestibuli resulted in a decrease in the cochlear microphonics, the action potential, and the endocochlear potential
. Moreover, hearing did not return to baseline levels in some cases after the air was removed.
This system helps to maintain the endocochlear potential
and the ionic composition of the endolymph .
Combined effects of adrenalectomy and noise exposure on compound action potentials, endocochlear potentials
and endolymphatic potassium concentrations.