endochondral ossification


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ossification

 [os″ĭ-fĭ-ka´shun]
formation of or conversion into bone or a bony substance.
ectopic ossification a pathological condition in which bone arises in tissues not in the osseous system and in connective tissues usually not manifesting osteogenic properties.
endochondral ossification ossification that occurs in and replaces cartilage.
heterotrophic ossification metaplastic ossification.
intramembranous ossification ossification of bone that occurs in and replaces connective tissue.
metaplastic ossification the development of bony substance in normally soft body structures; called also heterotrophic ossification.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

en·do·chon·dral os·si·fi·ca·tion

formation of osseous tissue by the replacement of calcified cartilage; long bones grow in length by endochondral ossification at the epiphysial cartilage plate where osteoblasts form bone trabeculae on a framework of calcified cartilage.
Farlex Partner Medical Dictionary © Farlex 2012

endochondral ossification

n.
The formation of bone in which a cartilage template is gradually replaced by a bone matrix, as in the formation of long bones or in osteoarthritic ossification of synovial cartilage.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

en·do·chon·dral os·si·fi·ca·tion

(en'dō-kon'drăl os'i-fi-kā'shŭn)
Formation of osseous tissue by the replacement of calcified cartilage; long bones grow in length by endochondral ossification at the epiphysial cartilage plate where osteoblasts form bone trabeculae on a framework of calcified cartilage.
Synonym(s): intrachondral ossification.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
Enlarge picture
ENDOCHONDRAL OSSIFICATION: Ossification process in a long bone; (A) progression from embryo to young adult, (B) microscopic view of an epiphyseal disk
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ENDOCHONDRAL OSSIFICATION

endochondral ossification

The formation of bone in cartilage, as in the formation of long bones, involving the destruction and removal of cartilage and the formation of osseous tissue in the space formerly occupied by the cartilage. See: illustration
illustration
See also: ossification
Medical Dictionary, © 2009 Farlex and Partners

endochondral ossification

Bone formation occurring within cartilage, in which cartilage is replaced by bone. This is the main process of bone formation and extension during fetal life and childhood.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

en·do·chon·dral os·si·fi·ca·tion

(en'dō-kon'drăl os'i-fi-kā'shŭn)
Formation of osseous tissue by replacement of calcified cartilage.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
In the present study, endogenous conversion of n-6 to n-3 PUFAs promotes terminal differentiation of endochondral ossification and accelerates remodeling of calcified callus in fracture healing of fat-1 mice.
We focused on roles of those proteins on proliferation and differentiation of chondrocytes in endochondral ossification and investigated the effects of TPD52 and TPD54 genes on the proliferation and differentiation of ATDC5 cells.
In the early intramembranous ossification and endochondral ossification stages of fracture-healing, the local expression of TGF-[beta]1 and BMP-2 was strongly increased at an early stage in the control group compared with the diabetes group, in all cells (osteogenic cells, osteoblasts in the subperiosteal bone, fibroblast-like cells, proliferating chondrocytes, mature chondrocytes, and osteoblasts in the trabecular bone near to the endochondral ossification front).
They are produced by a progressive endochondral ossification of a growing cartilaginous cap.
Myoui, "Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification," Journal of Biological Chemistry, vol.
Such a mineral phase indicated that in AKU aortic valve a process of endochondral ossification like in bone was occurring, as also evidenced by SEM images with collagen appearing as delicate bundles of fibres with a random orientation and exhibiting like bone concretions (Figure 2(a)B).
This however did not reflect for the lower values of lower facial height in prepubertal males, which was difficult to explain but may not be unrelated to the differential apposition in growth of the various endochondral ossification sites in the mandible, 2 anterior, present in the (symphysis and alveolar arch) and 2 posterior (condyle and coronoid).
(1,2) Within the normal intramembranous ossification, areas of endochondral ossification may also be present.
The development of antlers is a modified endochondral ossification process (Rucklidge et al., 1997), which is co-regulated by various biomolecules, including IGF-I, FGFs, TGF-b etc.
The pathogenesis of rickets involves impaired mineralization of physeal and epiphyseal cartilage during endochondral ossification and newly formed osteoid (McCarthy and Frassica, 1998).