5 mg/dl, n (%) Data are presented as mean [+ or -] SD and numbers (percentages) * unpaired t test and Chi-square test LVEF--left ventricular ejection fraction, LVVs--left ventricular end-systolic volume
, NT-pro BNP N--terminal pro-B-type natriuretic peptide, sPAP--Systolic pulmonary arterial pressure Q-left time, the time from the onset of the Q-wave on the surface ECG to the onset of the regional systolic motion of left ventricle (evaluated by TDI).
Patients with the CRT device turned on also had significantly improved left ventricular function, as reflected in their ejection fraction and end-diastolic and end-systolic volumes
CSD-treated patients showed dramatic improvements in left ventricular structure by three separate indices: reduced end-diastolic volume, reduced end-systolic volume
, and a reduced sphericity index indicative of a return to an elliptical ventricle shape.
Plasma big endothelin-1 concentrations exhibited a significant negative correlation with the left ventricular ejection fraction, and a significant positive correlation with the left ventricular end-diastolic pressure, the left ventricular end-diastolic and end-systolic volume
indices, and the mean and end-diastolic pulmonary arterial pressure.
In addition to LVEF improvements seen at 18 months, a measure of the heart's volume and size (left ventricular end-systolic volume
index, or LVESVi) improved with CRT from 95 ml/m2 at the start of the trial to 68 ml/m2 after 18 months.
Left ventricular end-systolic volume
index was measured echocardiographically after 1 year.
Severe aortic stenosis results in 1) reduced ventricular stroke volume due to increased after load, which decreases ejection velocity, 2) increased end-systolic volume
and 3) a compensatory increase in end diastolic volume and pressure.