Association between left ventricular end-diastolic pressure
and coronary artery disease as well as its extent and severity.
If the single-ventricle end-diastolic pressure
increases, the cause of increasing pulmonary arterial wedge pressure is considered to be single-ventricle dysfunction.
studied patients with clinical heart failure with a normal LVEF and plotted pressure volume loops that showed that, in patients with a normal LVEF, a small increase in LVEDVi results in an exponential increase in LV end-diastolic pressure
, indicating low compliance.
Asada et al., "Correlation between left ventricular end-diastolic pressure
and peak left atrial wall strain during left ventricular systole," Journal of the American Society of Echocardiography, vol.
We studied how the size of LVA affects not only the end-diastolic pressure
and the end-diastolic volume of the whole left ventricle, but also the end-diastolic volume of section S2 (that developed the LVA).
The accumulation of fluid in the pericardial space results in an increase in the intra-pericardial pressure, which, when exceeding the ventricular end-diastolic pressure
impairs ventricular filling, and so, reduces stroke volume and cardiac output.
Vaikus described three haemodynamic criteria for differentiating restrictive from constrictive pathology.3 (i) equalization of right ventricular end-diastolic pressure
(RVEDP) and left ventricular end-diastolic pressure
(LVEDP), with constriction more likely with a difference of less than 5 mmHg, (ii) elevation of right ventricular systolic pressures (RVSP) to greater than 50 mmHg with restriction, and less than 50 mmHg with constriction; and (iii) RVEDP ratio to RVSP exceeding one-third in constriction and less than one-third with restriction.
ATP turnover during low-flow ischemia was inversely related to recovery of the rate-pressure product (P = 0.002), end-diastolic pressure
(P = 0.007), and perfusion pressure (P = 0.05).
The association was independent of left ventricular ejection fraction and LV end-diastolic pressure
, although it is possible that high levels of the biomarker reflect subtle LV remodeling detectable only by MRI or other high-definition imaging methods not employed in this study.
(4,5) These pathologic changes to the pericardium cause the pressure in both ventricles to rise early in diastole, with elevation of the end-diastolic pressure
and reduction in ventricular filling.