Lower the machine needle down into the fabric precisely at the dart
end point, just one thread away from the fold (8).
Piolitazone Lowers Cardiovascular Event Risk in Diabetes Patients With Chronic Kidney Disease Pioglitazone Placebo (n = 274) (n = 323) Primary
end point 24% 31% Secondary
end point 15% 21% Source: Journal of the American Society of Nephrology Note: Table made from bar graph.
Although the development of in vitro methods is occurring more systematically than ever before, it continues to be a slow and uncertain procedure to model the complex biological processes that underlie toxicological assessments for
end points such as subchronic and chronic toxicity, reproductive toxicity, and carcinogenicity.
Given the lack of time and funding needed to study biomarkers extensively, there has been a strong push among biopharmaceutical industry players to explore innovative study designs that optimize the use of biomarkers as surrogate
end points.
The extension of efforts like these to incorporate toxicological and biological
end points critically defines and distinguishes toxicogenomic databases, and several key initiatives will be discussed here.
IP
end points are likely to gain visibility in the small and medium enterprise (SME) customer segment in the immediate future.
Proposed
end points include assessment of gamete quality, fecundity, gross pathology of gonads, measurement of relative gonad weight (gonadal somatic index), and measurement of vitellogenin levels (a widely used bio-marker of estrogen exposure in fish) (8,27).
They will improve hazard characterization through the use of biomarkers of response or effect with mechanistic linkage to
end points of concern.
Breakthrough Twin Beam Technology Enables Dedicated TEM and STEM Sample Preparation with More Artifact Free Sample Clarity and Precise
End Point Detection
Rambus digital controllers are available as root complex, switch port,
end point and hybrid (
end point/root complex) device types.
Codian products are
end point agnostic and deliver each conference participant the best possible audio and video quality; this makes them ideal for Chinese organizations that require frequent face-to-face communication across the country or have diverse
end point equipment or connection speeds.
Shenoy and his colleagues set out to shorten the process by focusing on the
end point rather than processing every step along the way.
