However, this was offset by a significant increase in the capacity to encapsidate
Gag and Pol, producing a large pool of defective virus-like particles (Figures 6(a) and 6(b)).
 Previous studies demonstrated that HPV16 VLP self-assembled from L1 protein could encapsidate
heterologous DNA up to 8.0 kb in vitro, and the pseudovirion can infect many kinds of cell lines.
C-terminus of the polyprotein encodes the coat protein (CP) which encapsidates
the viral genome through helical arrangement of its multiple subunits .
It is a structural protein which encapsidates
the viral genome into an RNAse-resistant nucleocapsid (the template for RNA synthesis) and together with phosphoprotein forms the ribonucleoprotein which constitutes the minimum essential for transcription and replication of viral genome in the cell cytoplasm (Knipe and Howley 2001).
The P protein acts as a bridge between the L protein and NP protein which encapsidates
the viral genome .