enantioselectivity


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enantioselectivity

(ē-nan'tē-ō-sē-lek-tiv'i-tē),
The difference in pharmacologic, pharmacodynamic, pharmacokinetic, therapeutic, and (adverse) side or toxic effects between enantiomers.
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
The highest enantioselectivity of [delta]-iodo-[gamma]-lactonization (18%ee) was also recorded for menthol ester 2a.
Despite some room for improvement, especially (i) improvement of the enantioselectivity of carboalumination and (ii) realization of higher turnover numbers through elevation of the current level of 20-[10.sup.3] to [greater than or equal to] [10.sup.3]-[10.sup.4] or higher, the ZACA reaction promises to provide a widely applicable, efficient, and selective asymmetric method for the synthesis of a variety of chiral organic compounds.
Considering that 1a containing pyrrolidinium cation gave the higher enantioselectivity than pyrrolidinepyrrolidine combined diamine catalyst [29], we propose that the electrostatic interaction with pyrrolidinium cation of 1a and nitro oxygen of trans-[beta]-nitrostyrene can form the transition state I and the steric hindrance of pyrrolidinium cation of 1a can shield the access of the nitro group.
The effect of enantioselectivity of 21 on the biological activity was also studied.
Enantioselectivity in the methylation of the catecholic phase I metabolites of methylenedioxy designer drugs and their capability to inhibit catechol-O-methyltransferase-catalyzed dopamine 3-methylation.
Among the topics are valence photoelectronic circular dichroism of gas phase enantiomers, the infrared and Raman detection of transient chirality recognition in the gas phase with ethanol as a case study, enantioselectivity in gas-phase ion-molecule reactions, equilibrium methods, deoxy oligonucliotides as chiral references for discriminating enantiomeric amino acids under mass spectrometry, solution-phase versus gas-phase chiral recognition by electrospray ionization mass spectrometry with a case study of two chiral selector classes.
They also exhibit good chemoselectivity, regioselectivity and enantioselectivity, and as hydrolases they do not require cofactors.
The results are in accordance to a reported result where enantioselectivity of other lipases toward primary alcohol is much lower than to secondary alcohol [11].
However, in spite of high enantioselectivity, the yield of the applied microbial Baeyer-Villiger reaction was low.
Reetz, A practical high-throughput screening system for enantioselectivity by using FTIR spectroscopy, Chemistry-A European J.