93) The issues in the salt cases have important similarities to the
enantiomer cases.
2009) Chiral polymers for resolution of
enantiomers.
The transmembrane pores having relatively small diameter might be responsible for the selective separation of
enantiomers.
A combination of methanol/acetonitrile/water in the mobile phase is mandatory for separation of HBCD
enantiomers [99].
Table 2 Effects of GBE and bilohalide on plasma concentration of warfarin and 7-hydroxywarfarin
enantiomers in mice given warfarin racemate.
A representative chromatogram showing resolution of derivatives of
enantiomers is shown in Fig-2.
Although a court must not declare that a prima facie case of obviousness exists for an
enantiomer over its prior art racemate in the absence of the Graham factual inquiries, (132) the structural similarities between a single
enantiomer and its racemate are usually sufficient to establish a prima facie case.
75) The five methods of separating
enantiomers were well-known, but the PHOSITA would have no knowledge of the relative advantage of the d-
enantiomer (clopidogrel).
But in December 2006 an appeals court found that the so-called 995
enantiomer patent had a technical defect in that one claim Within it contained an improper cross-reference to another claim in the patent.
Lundbeck A/S v Generics (UK) Limited & Ors, the English Court of Appeal reversed in part the decision of the Patents Court and in so doing upheld broad product claim protection for escitalopram, the (+)
enantiomer of the racemate citalopram, that is responsible for the SSRI activity of citalopram.
DIO-902 (levdexketoconazole) is an oral, single
enantiomer of ketoconazole that is a novel cortisol synthesis inhibitor in development for type 2 diabetes mellitus and diabetic nephropathy.
The
enantiomer, trade name Amplixa, has gotten the green light from the Food and Drug Administration for accelerated development on the strength of the reassuring safety profile established over many years by its racemic relative, mecamylamine, Dr.
