The two enantiomers
of a chemical can exhibit very distinct biological activity, therefore, enantioselective synthesis is of the utmost importance in the pharmaceutical industry.
A systematic evaluation of the LOD of the described method does not seem reasonable because even small optical impurities of the derivatization reagent would make the LOD of one enantiomer
dependent on the concentration of its optical antipode.
Because it's possible to create antibodies for an enormous range of molecules, antibody-laden membranes could do a host of molecule-sorting jobs beyond separating enantiomers
, says Mitchell.
As described previously, supplementation with a racemate of carnitine can have adverse effects, which may mimic actual deficiency of carnitine, perhaps via the enantiomers
competing for transport into cells (Watanabe S.
Furthermore, elimination of the S-(+) enantiomer
is faster than elimination of the R-(-) enantiomer
For instance, for insecticides known as synthetic pyrethroids, the toxicity of one enantiomer
proved to be 17 to 38 times that of the other.
Lipoic add is a stereoisomer (it has two closely related but not identical forms), an enantiomer
(the two forms are mirror images) and is chiral (the two mirror images are not super imposable).
The experimental data indicate that both the pure enantiomer
and its racemate induced, after systemic administration, a reduction of edema.
The levo enantiomer
of o,p'DDT inhibits the binding of 17[Beta]-estradiol to the estrogen receptor.
The predominant enantiomer
is t-(+)-isoleucine (2S-amino-3S-methylpentanoic acid).
Reflecting developments in both the science and the law, this edition includes treatment of new topics, including the impact of the International Conference on Harmonisation, IP and patent concerns with regard to racemic switches and the marketing of single enantiomer
switches, and the importance of stereochemistry on the ADMET stage of drug discovery.
The plasma concentration of (S)-warfarin was higher than that of (R)-warfarin even though the same dose of each enantiomer
was given; the mean [+ or -] SE (vehicle vs.