In a study that included more than 20,000 adults in China with high blood pressure, but without a history of stroke or heart attack, the combined use of the hypertension medication enalapril
and folic acid, compared with enalapril
alone, significantly reduced the risk of first stroke, according to a study published in JAMA.
In this study, diabetic (D) rats were treated as follows: D +vehicle (DC) treated with vehicle (100 ml propylene glycol ip), D + enalapril
(Hiral Labs Ltd, India) (EG; 25 mg/l in drinking water), D + paricalcitol (MedChemexpress, Princeton, NJ) (PG; 0.8 mg/kg ip, 3 weeks), or D + enalapril
+ paricalcitol (CG).
Afterwards, one of each of the four groups of high fat fed rats and diabetic rats were placed on the normal diet (obese and diabetic reversal groups), treated with enalapril
(500 mg/kg in the high fat diet, obese and diabetic enalapril
groups) or treated with menhaden oil by replacing 50% of the fat derived from lard in the high fat diet with menhaden oil (obese and diabetic menhaden oil groups) [1, 30].
In our case, patient had received enalapril
for 5 months before initiation of lisinopril; however patient developed symptoms 2 years after initiation of lisinopril.
(4) SHR treated with enalapril
(age: 4 weeks-28 weeks) and L-NAME (age: 16 weeks-28 weeks): SHR+E+LN.
The groups are as follows: control with no treatment (group C, n = 10); diabetes with no treatment (group DM, n= 10); diabetes treated with enalapril
, at a dose of 10 mg/kg body weight/day by gavage (group DM + E, n = 10), diabetes treated with breviscapine, at a dose of 20 mg/kg body weight/day by gavage (group DM + B, n= 10), diabetic rats treated with the combination of both enalapril
and breviscapine at the doses described above (group DM + E + B, n= 10).
It was found that a group of rats treated with enalapril
0.5mg/kg (n = 35), index of microcirculation was 93.3 [+ or -] 4.4 perfusion units PU and the animals with losartan 6 mg/kg (n = 35), 100.0 [+ or -]2.3 perfusion units PU.
American Journal of Medicine, found that the incidence of ACE inhibitor-associated cough was significantly higher than the rate reported in the Physicians' Desk Reference (PDR) and on the drug label (11.48 percent versus the 1.3 percent for enalapril
Mauer's study demonstrated that participants who were administered either enalapril
or losartan experienced a significant slowing of the progression of diabetic eye injury, by 65 and 70 percent, respectively.
His regular enalapril
dose was omitted as his blood pressure was around 110 mmHg systolic on the day.
The product, a combination of the pharmaceutical substances lercanidipine (calcium antagonist) and enalapril
(an ACE inhibitor), is used for the treatment of high blood pressure.