KEYWORDS: Empty sella syndrome, Hypopituitarism, Panhypopituitarism, Sheehan's syndrome.
Sixteen patients had secondary infertility and all were females; a majority of patients in this group had Sheehan's syndrome (n=8) followed by empty sella syndrome (n=3), partial empty sella syndrome (n=2), idiopathic cause (n=2) and tuberculoma (n=1).
The commonest pituitary lesion was Prolactinoma in 26 (26.8%) patients, followed by Sheehan's syndrome in 13 (13.4%) patients, Acromegaly in 12 (12.4%), non-secretory pituitary adenoma in 12 (12.3%), Hypogonadotropic hypogonadism in 10 (10.3%) and Craniopharyngioma in 7 (7.2%) patients, while miscellaneous disorders including Pan hypopituitarism, Cushing's disease, Empty sella syndrome
, Ectopic Cushing's, Diabetes Insipidus, Autoimmune hypophysitis, TSHoma and Suprasellar mass etc.
Even though it was related to the obesity, toxins, medications, hypo- and hyper-vitaminosis, collagen tissue diseases, intracranial venous sinus thrombosis, and empty sella syndrome
, the etiology of this clinical condition is not clear yet (1).
Kartha, "Psychosis in secondary empty sella syndrome
following a Russell's viper bite," Indian Journal of Psychological Medicine, vol.
Men with empty sella syndrome
had significantly higher prolactin, compared with men who had normal MRIs (21.4 ng/mL vs.
(4,5,6,7) Empty sella syndrome
, panhypopituitarism, diabetes insipidus, short stature and obesity in a 18 months old baby probably secondary to obstetrics insult was also reported.
12(7%) cases of complete/partial empty sella syndrome
It develops from bilateral involvement of the uncrossed fibers at the chiasma such as bilateral internal carotid artery atherosclerosis or aneurysm, olfactory groove meningioma, empty sella syndrome
, chronic raised intracranial pressure, and neurosyphilis affecting both optic nerves.
But it is doubtful that they would know diseases such as West Syndrome, Whipple's disease, Buerger's disease, yellow-nail syndrome, empty sella syndrome
, or Job (as in the Old Testament) syndrome.
d/h Hypo pituitarism has varied etiology, most common being pituitary adenomas (Macro 75 % and others 20%), Sheehan syndrome, familial hypopituitarism, idiopathic, hypophysitis, empty sella syndrome
, snake bite being other causes.
37, 8 Ectopic production Breastfeeding Breast stimulation Hypothyroidism Medications Empty sella syndrome
Pituitary adenoma Autoimmune Chemotherapy Galactosemia Genetic 17-hydroxylase deficiency syndrome Idiopathic Mumps Pelvic radiation Chronic liver disease Chronic renal insufficiency Diabetes Immunodeficiency Inflammatory bowel disease Thyroid disease Severe depression or psychosocial stressors Acromegaly Androgen-secreting tumor (ovarian or adrenal) Cushing's disease Exogenous androgens Polycystic ovary syndrome Thyroid disease Asherman's syndrome Cervical stenosis TABLE 4: Causes of secondary amenorrhea in study group.